Operations Research, Systems Engineering and Industrial Engineering Commons^™

Prediction Of Growth Factor Effects On Engineered Cartilage Composition Using Deterministic And Stochastic Modeling, Sean S. Kohles, Asit K. Saha, J. (Jagannath) Mazumdar

Mechanical and Materials Engineering Faculty Publications and Presentations

In the design of engineered tissues, guided balance of biomaterial degeneration with tissue synthesis offers refined control of construct development. The objective of this study was to develop a mathematical model that describes the steady state metabolism of extracellular matrix molecules (ECM: glycosaminoglycan and collagen) in an engineered cartilage construct taking into account localized environmental changes that may arise because of the application of growth factors. The variable effects of growth factors were incorporated in the form of random noise rather than the difference in rates of synthesis and catabolism. Thus, the frequency of ECM accumulation for each matrix molecule …