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Operations Research, Systems Engineering and Industrial Engineering Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Exact Models, Heuristics, And Supervised Learning Approaches For Vehicle Routing Problems, Zefeng Lyu
Exact Models, Heuristics, And Supervised Learning Approaches For Vehicle Routing Problems, Zefeng Lyu
Doctoral Dissertations
This dissertation presents contributions to the field of vehicle routing problems by utilizing exact methods, heuristic approaches, and the integration of machine learning with traditional algorithms. The research is organized into three main chapters, each dedicated to a specific routing problem and a unique methodology. The first chapter addresses the Pickup and Delivery Problem with Transshipments and Time Windows, a variant that permits product transfers between vehicles to enhance logistics flexibility and reduce costs. To solve this problem, we propose an efficient mixed-integer linear programming model that has been shown to outperform existing ones. The second chapter discusses a practical …
Understanding And Simulating Wildfire Changes Using Advanced Statical And Process-Oriented Models, Rongyun Tang
Understanding And Simulating Wildfire Changes Using Advanced Statical And Process-Oriented Models, Rongyun Tang
Doctoral Dissertations
This study aims to investigate the spatiotemporal dynamic of global wildfires, their underlying climate-driving mechanisms, and their predictability by utilizing multiple data sources (both process-based model simulations and satellite-based observations) and multiple analytical methods including machine learning techniques (MLTs).
We first explored the global wildfire interannual variability (IAV) and its climate sensitivity across nine biomes from 1997 to 2018, leveraging the state-of-art U.S. Department of Energy’s Energy Exascale Earth System Model (E3SM) land component (ELM-v1) simulations with six sets of climate forcings. Results indicate that 1) ELM simulations could reproduce the IAV of wildfire in terms of magnitudes, distribution, bio-regional …
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
Masters Theses
One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …