Operations Research, Systems Engineering and Industrial Engineering Commons^™

A Systems Approach To Point Source Indication Of Metformin Found In Local Water Systems – The Case Of Milwaukee County, Mohamed Salem Baitelmal

Theses and Dissertations

Pharmaceutical pollutants are present in traceable concentrations in Milwaukee County water system and Lake Michigan. The actual point sources and nature of entry into the water system is difficult to determine with certainty. Pharmaceuticals have been found to persist at the South Shore Wastewater Treatment Facility (SSWTF) in Milwaukee, Wisconsin. The highest concentration was found to be for the pharmaceutical drug metformin. Metformin is a first line drug for the treatment of type 2 diabetes mellitus.

The broad goal of this exploratory study; the first of its kind, is to correlate trace concentrations of drugs to the point sources. Particularly, …

Optimal Cyclic Control Of A Buffer Between Two Consecutive Non-Synchronized Manufacturing Processes, Wenhuan Hsieh

Theses and Dissertations

This thesis presents methods for efficiently controlling a buffer that is located between two non-synchronized manufacturing processes. Several machines with different cycle times and/or batch sizes perform each manufacturing process. The overall operation cycles every T time units. The first objective of the problem is to minimize the average buffer inventory level during one cycle. The second objective is to minimize the maximum inventory level observed at any point during the cycle. This new optimization problem has not been previously considered in the literature. An integer program is developed to model this problem. In addition, two heuristic methods—a simulated annealing …