Operations Research, Systems Engineering and Industrial Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Analyzing Sensor Based Human Activity Data Using Time Series Segmentation To Determine Sleep Duration, Yogesh Deepak Lad

Masters Theses

"Sleep is the most important thing to rest our brain and body. A lack of sleep has adverse effects on overall personal health and may lead to a variety of health disorders. According to Data from the Center for disease control and prevention in the United States of America, there is a formidable increase in the number of people suffering from sleep disorders like insomnia, sleep apnea, hypersomnia and many more. Sleep disorders can be avoided by assessing an individual's activity over a period of time to determine the sleep pattern and duration. The sleep pattern and duration can be …

Developing Leading And Lagging Indicators To Enhance Equipment Reliability In A Lean System, Dhanush Agara Mallesh

Masters Theses

With increasing complexity in equipment, the failure rates are becoming a critical metric due to the unplanned maintenance in a production environment. Unplanned maintenance in manufacturing process is created issues with downtimes and decreasing the reliability of equipment. Failures in equipment have resulted in the loss of revenue to organizations encouraging maintenance practitioners to analyze ways to change unplanned to planned maintenance. Efficient failure prediction models are being developed to learn about the failures in advance. With this information, failures predicted can reduce the downtimes in the system and improve the throughput.

The goal of this thesis is to predict …

Explorations Into Machine Learning Techniques For Precipitation Nowcasting, Aditya Nagarajan

Masters Theses

Recent advances in cloud-based big-data technologies now makes data driven solutions feasible for increasing numbers of scientific computing applications. One such data driven solution approach is machine learning where patterns in large data sets are brought to the surface by finding complex mathematical relationships within the data. Nowcasting or short-term prediction of rainfall in a given region is an important problem in meteorology. In this thesis we explore the nowcasting problem through a data driven approach by formulating it as a machine learning problem.

State-of-the-art nowcasting systems today are based on numerical models which describe the physical processes leading to …

A Bounded Actor-Critic Algorithm For Reinforcement Learning, Ryan Jacob Lawhead

Masters Theses

"This thesis presents a new actor-critic algorithm from the domain of reinforcement learning to solve Markov and semi-Markov decision processes (or problems) in the field of airline revenue management (ARM). The ARM problem is one of control optimization in which a decision-maker must accept or reject a customer based on a requested fare. This thesis focuses on the so-called single-leg version of the ARM problem, which can be cast as a semi-Markov decision process (SMDP). Large-scale Markov decision processes (MDPs) and SMDPs suffer from the curses of dimensionality and modeling, making it difficult to create the transition probability matrices (TPMs) …

A New Reinforcement Learning Algorithm With Fixed Exploration For Semi-Markov Decision Processes, Angelo Michael Encapera

Masters Theses

"Artificial intelligence or machine learning techniques are currently being widely applied for solving problems within the field of data analytics. This work presents and demonstrates the use of a new machine learning algorithm for solving semi-Markov decision processes (SMDPs). SMDPs are encountered in the domain of Reinforcement Learning to solve control problems in discrete-event systems. The new algorithm developed here is called iSMART, an acronym for imaging Semi-Markov Average Reward Technique. The algorithm uses a constant exploration rate, unlike its precursor R-SMART, which required exploration decay. The major difference between R-SMART and iSMART is that the latter uses, in addition …

Rote-Lcs Learning Classifier System For Classification And Prediction, Benjamin Daniels

Masters Theses

"Machine Learning (ML) involves the use of computer algorithms to solve for approximate solutions to problems with large, complex search spaces. Such problems have no known solution method, and search spaces too large to allow brute force search to be feasible. Evolutionary algorithms (EA) are a subset of machine learning algorithms which simulate fundamental concepts of evolution. EAs do not guarantee a perfect solution, but rather facilitate convergence to a solution of which the accuracy depends on a given EA's learning architecture and the dynamics of the problem.

Learning classifier systems (LCS) are algorithms comprising a subset of EAs. The …

An Integrated Simulation Model Development Environment For Slam Ii Using Object-Oriented Paradigm, Rizvan Erol

Masters Theses

An integrated simulation model development environment was implemented to assist the modeler by automating certain activities of simulation modeling. The system included interactive model definition, experimental design, automatic simulation program generation in SLAM II. Object-oriented paradigm at software development stage was extensively used to conceptualize the structure, and rules of the SLAM II language in order to generate efficient, and modular program code. The present system targeted modeling of various probabilistic inventory control system problems. The remarkable advantages of the system were rapid model development time, and achieving reliable program code without requiring any knowledge in SLAM II. Object-oriented programming …

Mocad: A Graphic Predetermined Time Standards Software For The Ibm P.C., Raad A. Dawood

Masters Theses

MODCAD is a software program designed to give MODAPTS (MODular Arrangement of Predetermined Time Standards) the capability to generate workplace layouts that can be used in conjunction with the time study analysis. Software packages have been developed for MODAPTS such as MODAPTS Plus and Task Master that allow the user to input the predetermined codes of MODAPTS.

AutoCAD (a computer aided design software) is used to combine MODAPTS codes and workplace layout drawings in a single environment by customizing the standard AutoCAD menus and icons to include the MODAPTS codes and routines. AutoLisp (AutoCAD resident language) is used to write …