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Full-Text Articles in Nuclear Engineering
Production Of Medical Radioisotopes Using Titanium Accelerator Targets, Christopher Shaun Loveless
Production Of Medical Radioisotopes Using Titanium Accelerator Targets, Christopher Shaun Loveless
Arts & Sciences Electronic Theses and Dissertations
Theranostic radiopharmaceuticals enable diagnostic imaging and radionuclide therapy in patients using a single molecular agent labeled with a diagnostic-therapeutic pair (e.g., 68Ga/177Lu) or a theranostic radionuclide (e.g., 131I). This theranostic approach can help inform patient-specific treatment plans and improve clinical outcomes. Radionuclide pairs used in theranostic agents fall into two categories: pseudo matched-pairs (e.g., 68Ga/177Lu) and matched-pairs (e.g., 124I/131I). Pseudo matched-pair radionuclides have similar chemistries and pharmacokinetics when bound to the same bioconjugate molecule. In contrast, identical chemistries and pharmacokinetics can be obtained by using the matched-pair radionuclides.
The isotopes of Sc include two diagnostic radioisotopes, 43Sc & 44Sc, and …