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Full-Text Articles in Nanoscience and Nanotechnology
Ultrastable Synergistic Tetravalent Rna Nanoparticles For Targeting To Cancers, Farzin Haque, Dan Shu, Yi Shu, Luda S. Shlyakhtenko, Piotr G. Rychahou, B. Mark Evers, Peixuan Guo
Ultrastable Synergistic Tetravalent Rna Nanoparticles For Targeting To Cancers, Farzin Haque, Dan Shu, Yi Shu, Luda S. Shlyakhtenko, Piotr G. Rychahou, B. Mark Evers, Peixuan Guo
Pharmaceutical Sciences Faculty Publications
One of the advantages of nanotechnology is the feasibility to construct therapeutic particles carrying multiple therapeutics with defined structure and stoichiometry. The field of RNA nanotechnology is emerging. However, controlled assembly of stable RNA nanoparticles with multiple functionalities which retain their original role is challenging due to refolding after fusion. Herein, we report the construction of thermodynamically stable X-shaped RNA nanoparticles to carry four therapeutic RNA motifs by self-assembly of reengineered small RNA fragments. We proved that each arm of the four helices in the X-motif can harbor one siRNA, ribozyme, or aptamer without affecting the folding of the central …
Characterization And Manipulation Of Nanorods Via An Applied Magnetic Field, Summer Wu '13
Characterization And Manipulation Of Nanorods Via An Applied Magnetic Field, Summer Wu '13
Student Publications & Research
A remote system capable of controlling the motion of magnetic nanorods was created. Two different systems, electromagnets and magnetic stirrers, were used to create continuously changing magnetic fields thus applying a constant torque to make nanorods rotate as “nano stirbars”. The system was tested on three different types of synthesized nanorods: multi-segmented Ni/Au, pure Ni, and pure Au nanorods. Ni and Au were chosen due to the combination of the magnetic properties of Ni and the biocompatible properties of Au. Variables such as length, shape, and geometries of the nanorods were characterized by a scanning electron microscope and an atomic …