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Full-Text Articles in Nanoscience and Nanotechnology
Investigating Mechanisms Of Nanotoxicity Of A Next-Generation Lithium Cobalt Oxide Nanomaterial, Nicholas Joseph Niemuth
Investigating Mechanisms Of Nanotoxicity Of A Next-Generation Lithium Cobalt Oxide Nanomaterial, Nicholas Joseph Niemuth
Theses and Dissertations
Commercial use of engineered nanomaterials (ENMs; materials in the range of 1-100 nm) has grown dramatically since the discovery of the means to observe, characterize, and controllably synthesize these materials at the end of the 20th century. Today, ENMs represent a global market valued in the trillions of dollars, incorporated into products because of the unique properties they confer, including increased strength, catalytic activity, and interactions with light. In this time, ENMs have also grown from relatively simple first-generation materials, such as Au, Ag, and carbon ENMs, to complex next-generation materials incorporating numerous elements into materials with complex secondary structures, …
Exploration Of Antimicrobial And Cell Proliferation Properties Of Nanofibers Incorporating Nopal (O. Cochenillifera) Extract, Cristobal Rodriguez
Exploration Of Antimicrobial And Cell Proliferation Properties Of Nanofibers Incorporating Nopal (O. Cochenillifera) Extract, Cristobal Rodriguez
Theses and Dissertations
This study focused on the fabrication of Forcespinning® nanofibers composed of Opuntia cochenillifera, ‘nopal’, mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL) were developed with an optimum fiber average diameter of 406±127 nm, and studied for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, while also exhibiting inhibitory properties through an N extract dip-coating process against gram-negative bacteria Escherichia coli in a 24 h bacterial growth study. A demonstration of integrated natural bioactive compounds with combined biodegradable polymers, provide an enhanced …
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Theses and Dissertations
Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …