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Full-Text Articles in Nanoscience and Nanotechnology
Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
McKelvey School of Engineering Theses & Dissertations
Antibody-antigen recognition enables antibody-conjugated nanostructures to serve as plasmonic biosensors with tunable specificity. However due to the instability of antibodies, these biosensors are susceptible to changes in the environment such as heat and aridity, leading to constraints on the transportation and handling of these sensors. Here we establish a method using a metal-organic framework crystal to preserve biosensor activity under severe environmental conditions, including exposure to high temperatures, an organic solvent and a proteolytic agent. After zeolitic imidazolate framework-8 (ZIF-8) crystals formed for 12 hours on a biosensor of gold nanorods conjugated with a model antibody, rabbit IgG, 80% of …
Development And Evaluation Of A Near-Infrared (1047 Nm) Photoacoustic-Nephelometer Spectrometer For Detection And Optical Characterization Of Black Carbon Aerosol, Yang Yu
McKelvey School of Engineering Theses & Dissertations
Black carbon (BC) aerosol are aggregates of small carbon spherules of <10 nm to approximately 50 nm in diameter. They are characterized by their strong visible light absorption property with a mass absorption cross-section (MAC) value above 5 m2 g −1 at a wavelength λ = 550 nm, which increases inversely with wavelengths from near-infrared (≈1 µm) to ultraviolet with a power law of one. The absorbing nature of BC aerosol has been implicated in regional atmospheric warming, changing of monsoon patterns, and accelerated melting of the glaciers. The BC radiative effects over earth is currently estimated within a factor of four, resulting in one of the largest uncertainties in climate modeling. This uncertainty results from our inadequate knowledge about regional BC emission rates, and associated aerosol …
Contact Radius And Insulator-Metal Transition In Films Comprised Of Touching Semiconductor Nanocrystals, Deanna M. Lanigan
Contact Radius And Insulator-Metal Transition In Films Comprised Of Touching Semiconductor Nanocrystals, Deanna M. Lanigan
McKelvey School of Engineering Theses & Dissertations
Nanocrystal assemblies are being explored for a number of optoelectronic applications such as transparent conductors, photovoltaic solar cells, and electrochromic windows. Majority carrier transport is important for these applications, yet it remains relatively poorly understood in films comprised of touching nanocrystals. Specifically, the underlying structural parameters expected to determine the transport mechanism have not been fully elucidated. In this report, we demonstrate experimentally that the contact radius, between touching heavily doped ZnO nanocrystals, controls the electron transport mechanism. Spherical nanocrystals are considered, which are connected by a circular area. The radius of this circular area is the contact radius. For …
Feed-Forward Inhibitory Circuits In Hippocampus And Their Computational Role In Fragile X Syndrome, Sarah Lauren Wahlstrom Helgren
Feed-Forward Inhibitory Circuits In Hippocampus And Their Computational Role In Fragile X Syndrome, Sarah Lauren Wahlstrom Helgren
McKelvey School of Engineering Theses & Dissertations
Feed-forward inhibitory (FFI) circuits are canonical neural microcircuits. They are unique in that they are comprised of excitation rapidly followed by a time-locked inhibition. This sequence provides for a powerful computational tool, but also a challenge in the analysis and study of these circuits. In this work, mechanisms and computations of two hippocampal FFI circuits have been examined. Specifically, the modulation of synaptic strength of the excitation and the inhibition is studied during constant-frequency and naturalistic stimulus patterns to reveal how FFI circuit properties and operations are dynamically modulated during ongoing activity. In the first part, the FFI circuit dysfunction …