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Full-Text Articles in Nanoscience and Nanotechnology
Focal Adhesion Kinase Regulation In Stem Cell Alignment And Spreading On Nanofibers, Mohammad Nahid Andalib, Jeong Soon Lee, Ligyeom Ha, Yuris A. Dzenis, Jung Yul Lim
Focal Adhesion Kinase Regulation In Stem Cell Alignment And Spreading On Nanofibers, Mohammad Nahid Andalib, Jeong Soon Lee, Ligyeom Ha, Yuris A. Dzenis, Jung Yul Lim
Department of Mechanical and Materials Engineering: Faculty Publications
While electrospun nanofibers have demonstrated the potential for novel tissue engineering scaffolds, very little is known about the molecular mechanism of how cells sense and adapt to nanofibers. Here, we revealed the role of focal adhesion kinase (FAK), one of the key molecular sensors in the focal adhesion complex, in regulating mesenchymal stem cell (MSC) shaping on nanofibers. We produced uniaxially aligned and randomly distributed nanofibers from poly(L-lactic acid) to have the same diameters (about 130 nm) and evaluated MSC behavior on these nanofibers comparing with that on flat PLLA control. C3H10T1/2 murine MSCs exhibited upregulations in FAK expression and …