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Integration Of Flow Studies For Robust Selection Of Mechanoresponsive Genes, Nataly Maimari, Ryan M. Pedrigi, Alessandra Russo, Krysia Broda, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

Blood flow is an essential contributor to plaque growth, composition and initiation. It is sensed by endothelial cells, which react to blood flow by expressing >1000 genes. The sheer number of genes implies that one needs genomic techniques to unravel their response in disease. Individual genomic studies have been performed but lack sufficient power to identify subtle changes in gene expression. In this study, we investigated whether a systematic meta-analysis of available microarray studies can improve their consistency.

We identified 17 studies using microarrays, of which 6 were performed in vivo and 11 in vitro. The in vivo studies were …