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Dendrimers, Oral Inhalation, PEGylation, Polymeric Nanocarriers, Pulmonary Drug Delivery, Transport Modulation
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Full-Text Articles in Nanoscience and Nanotechnology
Polymeric Nanocarriers For The Regional And Systemic Delivery Of Therapeutics To And Through The Lungs, Balaji Bharatwaj
Polymeric Nanocarriers For The Regional And Systemic Delivery Of Therapeutics To And Through The Lungs, Balaji Bharatwaj
Wayne State University Dissertations
The lungs are considered as one of the fastest portals of entry to the bloodstream and oral inhalation (OI) has long been accepted as the preferred mode of administration of therapeutics to the respiratory tract. However, despite its advantages, the lungs have been largely underutilized to target ailments not only of systemic relevance but also several other grave conditions including lung cancer and tuberculosis. Polymeric nanocarriers (PNCs) have several advantages over other drug delivery vehicles including sustained release of moieties, ease of cellular internalization and improved targeting, and hence hold the promise to greatly augment the potential of OI therapies. …