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Electrochemical Studies On Surface Inclusion Of Β-Cyclodextrin With Adriamycin, Jian Shi, Qi-Ping Zhang, Nan-Ping Wang
Electrochemical Studies On Surface Inclusion Of Β-Cyclodextrin With Adriamycin, Jian Shi, Qi-Ping Zhang, Nan-Ping Wang
Journal of Electrochemistry
The β-cyclodextrin (β-CD) modified gold electrode (β-CD/Au) was fabricated to study the electrochemical behavior of adriamycin (ADM). The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface. At 25 ℃，the complexing constant (K) was 9.54×104 L?mol-1 in pH=7.0. The K values changed regularly with temperature, and the most suitable temperature of the surface inclusion reaction was 30 ℃. The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1. The cathodic peak current (Ip) of ADM was proportional to the …