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Full-Text Articles in Nanoscience and Nanotechnology

Nanoformulation For Anticancer Drug Delivery: Enhanced Pharmacokinetics And Circulation, Gaurav Parekh Jul 2015

Nanoformulation For Anticancer Drug Delivery: Enhanced Pharmacokinetics And Circulation, Gaurav Parekh

Doctoral Dissertations

In this study, we have explored the application of the Layer-by-Layer (LbL) assembly technique for improving injectable drug delivery systems of low soluble anticancer drugs (e.g. Camptothecin (CPT), Paclitaxel (PTX) or Doxorubicin (DOX)). For this study, a polyelectrolyte shell encapsulates different types of drug nanocores (e.g. soft core, nanomicelle or solid lipid nanocores).The low soluble drugs tend to crystallize and precipitate in an aqueous medium. This is the reason they cannot be injected and may have low concentrations and low circulation time in the blood. Even though these drugs when present in the cancer microenvironment have high ...


Nanoenhanced Additive Manufacturing: Additive Introduction Onto Halloysite Nanotubes And Into 3d Printing Filament For Tailored Material Characteristics, James Connor Nicholson Jul 2015

Nanoenhanced Additive Manufacturing: Additive Introduction Onto Halloysite Nanotubes And Into 3d Printing Filament For Tailored Material Characteristics, James Connor Nicholson

Doctoral Dissertations

With the rapid advancement of additive manufacturing technologies in recent years on both the microscale and the macroscale, research must be done to test the limits of currently available technologies. On the microscale, halloysite nanotubes have proven to be a viable platform for reinforcement of polymers and time release of loaded chemicals, as well as a substrate material for the deposition of nanoparticles. The range of materials are limited due to polarity conflicts, and often lead to wet chemical processes that use more toxic alternatives. Three-dimensional (3D) printing and macroscale additive manufacturing techniques can be used to generate custom structures ...


Functional Clay Nanotubes And Composites, Yafei Zhao Apr 2015

Functional Clay Nanotubes And Composites, Yafei Zhao

Doctoral Dissertations

Tubular nanomaterials and their composites have been extensively studied in recent years in the fields of physics, chemistry, biology, and biomedicine. Carbon nanotube is the most commonly studied tubular nanomaterial; however, toxicity and high cost make it less attractive in industry and thus restricts its applications. Halloysite nanotubes, which are available in abundance in the United States as well as in other countries around the world, is a low-cost, unique and versatile aluminosilicate mineral with a chemical formula of Al4Si4O10(OH)8┬ĚnH2O. Basically, the halloysite tube diameter is around 50 nm and the length varies with different locations ranging ...


Improving Practices In Nanomedicine Through Near Real-Time Pharmacokinetic Analysis, Isidro B. Magana Jan 2015

Improving Practices In Nanomedicine Through Near Real-Time Pharmacokinetic Analysis, Isidro B. Magana

Doctoral Dissertations

More than a decade into the development of gold nanoparticles, with multiple clinical trials underway, ongoing pre-clinical research continues towards better understanding in vivo interactions. The goal is treatment optimization through improved best practices. In an effort to collect information for healthcare providers enabling informed decisions in a relevant time frame, instrumentation for real-time plasma concentration (multi-wavelength photoplethysmography) and protocols for rapid elemental analysis (energy dispersive X-Ray fluorescence) of biopsied tumor tissue have been developed in a murine model. An initial analysis, designed to demonstrate the robust nature and utility of the techniques, revealed that area under the bioavailability curve ...