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Peptoid-Functionalized Gold Nanoparticles For Zika Virus Envelope Protein Detection, Meagan Olsen
Peptoid-Functionalized Gold Nanoparticles For Zika Virus Envelope Protein Detection, Meagan Olsen
Chemical Engineering Undergraduate Honors Theses
Detection and identification of viral pathogens is essential in providing effective and rapid medical treatment. Well-established detection methods can be expensive, slow, and sometimes unable to provide the needed sensitivity and specificity. The Zika virus is one clinically relevant pathogen that cannot be easily identified due to cross-reactivity with other viruses from the same family. Electrochemical sensors enhanced with peptoid-functionalized gold nanoparticles (AuNPs) are an alternative to traditional techniques that offers rapid, accurate, label-free pathogen detection for point-of-care diagnostics. To this end, a peptoid capable of binding to the Zika virus envelope protein was developed and its binding affinity for …
Peptoid Based Slide Coatings For Disease Detection Via Elisa Microarray Analysis, Melissa Lea Hebert
Peptoid Based Slide Coatings For Disease Detection Via Elisa Microarray Analysis, Melissa Lea Hebert
Graduate Theses and Dissertations
Poly-N-substituted glycines (peptoids) are a very versatile family of synthetic molecules that can be customized for any number of applications. In this study, we chose to use peptoids as a foundation for sandwich ELISA microarray analysis with a long term goal of creating an early detection device for complex diseases such as cancer. The peptoids were designed to self-assemble into microspheres to be used in coatings on the surface of the microarray substrates to increase the surface area available for antibody attachment. This increased antibody density would lead to an increase in the microarray analysis sensitivity and dynamic range. Studies …