Nanoscience and Nanotechnology Commons^™

Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski

Department of Mechanical and Materials Engineering: Faculty Publications

In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D …