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- Keyword
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- CANCER; NANOPARTICLES; THERAPY; ABSORPTION; GROWTH; RADIATION; CLUSTERS; LIGHT; SHAPE; SIZE (1)
- Carbon nanotube; field-effect transistor; 1/f noise (1)
- Carrier injection; Schottky-barrier (SB)-MOSFET; ultrathin-body silicon-on-insulator (SOI) (1)
- Coulomb interaction; nanowire; Schottky-barrier-field-effect transistors (SB-FETs) (1)
- FIELD-EFFECT TRANSISTORS (1)
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- FIELD-EFFECT TRANSISTORS; ROPES (1)
- FOLIC-ACID FORTIFICATION; METASTATIC BREAST-CANCER; FOLATE RECEPTOR; OVARIAN-CANCER; PERIPHERAL-BLOOD; BINDING; TISSUES; ENDOCYTOSIS; CARCINOMAS; MICROSCOPY (1)
- Folate conjugates; in vivo imaging; multiphoton microscopy; metastasis; cancer diagnosis (1)
- Folate receptor; hyperthermia; imaging; nanorods; nonlinear optical microscopy; plasmon resonance; targeted therapy (1)
- SOI-MOSFETS; DOPANT SEGREGATION; SI MOSFET; PERFORMANCE; SCATTERING; IMPACT (1)
Articles 1 - 7 of 7
Full-Text Articles in Nanoscience and Nanotechnology
Gold Nanorods Mediate Tumor Cell Death By Compromising Membrane Integrity, Ling Tong, Yan Zhao, Terry B. Huff, Matthew N. Hansen, Alexander Wei, Ji-Xin Cheng
Gold Nanorods Mediate Tumor Cell Death By Compromising Membrane Integrity, Ling Tong, Yan Zhao, Terry B. Huff, Matthew N. Hansen, Alexander Wei, Ji-Xin Cheng
Other Nanotechnology Publications
Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.
In Vivo Quantitation Of Rare Circulating Tumor Cells By Multiphoton Intravital Flow Cytometry, Wei He, Haifeng Wang, Lynn C. Hartmann, Ji-Xin Cheng, Phillip S. Low
In Vivo Quantitation Of Rare Circulating Tumor Cells By Multiphoton Intravital Flow Cytometry, Wei He, Haifeng Wang, Lynn C. Hartmann, Ji-Xin Cheng, Phillip S. Low
Other Nanotechnology Publications
Quantitation of circulating tumor cells (CTCs) constitutes an emerging tool for the diagnosis and staging of cancer, assessment of response to therapy, and evaluation of residual disease after surgery. Unfortunately, no existing technology has the sensitivity to measure the low numbers of tumor cells (< 1 CTC per ml of whole blood) that characterize minimal levels of disease. We present a method, intravital flow cytometry, that noninvasively counts rare CTCs in vivo as they flow through the peripheral vasculature. The method involves i.v. injection of a tumor-specific fluorescent ligand followed by multiphoton fluorescence imaging of superficial blood vessels to quantitate the flowing CTCs. Studies in mice with metastatic tumors demonstrate that CTCs can be quantitated weeks before metastatic disease is detected by other means. Analysis of whole blood samples from cancer patients further establishes that human CTCs can be selectively labeled and quantitated when present at approximate to 2 CTCs per ml, opening opportunities for earlier assessment of metastatic disease.
Physics Of Ultrathin-Body Silicon-On-Insulator Schottky-Barrier Field-Effect Transistors, Joachim Knoch, M Zhang, Joerg Appenzeller, S Mantl
Physics Of Ultrathin-Body Silicon-On-Insulator Schottky-Barrier Field-Effect Transistors, Joachim Knoch, M Zhang, Joerg Appenzeller, S Mantl
Other Nanotechnology Publications
In this article we give an overview over the physical mechanisms involved in the electronic transport in ultrathin-body SOI Schottky-barrier MOSFETs. A strong impact of the SOI and gate oxide thickness on the transistor characteristics is found and explained using experimental as well as simulated data. We elaborate on the influence of scattering in the channel and show that for a significant barrier the on-state current is insensitive to scattering once the mean free path for scattering is larger than a characteristic length scale. In addition, recent efforts to lower the Schottky barrier at the source/drain channel interfaces are presented. …
Understanding Coulomb Effects In Nanoscale Schottky-Barrier-Fets, Klaus M. Indlekofer, Joachim Knoch, Joerg Appenzeller
Understanding Coulomb Effects In Nanoscale Schottky-Barrier-Fets, Klaus M. Indlekofer, Joachim Knoch, Joerg Appenzeller
Other Nanotechnology Publications
We employ a novel multiconfigurational self-consistent Green's function approach (MCSCG) for the simulation of nanoscale Schottky-barrier-field-effect transistors (SB-FETs). This approach allows the calculation of electronic transport with a seamless transition from the single-electron regime to room-temperature FET operation. The particular improvement of the MCSCG stems from a self-consistent division of the channel system into a small subsystem of resonantly trapped states for which a many-body Fock space approach becomes numerically feasible and the rest of the system which can be treated adequately on a conventional mean-field level. The Fock space description allows for the calculation of few-electron Coulomb charging effects …
1/F Noise In Carbon Nanotube Devices - On The Impact Of Contacts And Device Geometry, Joerg Appenzeller, Yu-Ming Lin, Joachim Knoch, Zhihong Chen, Phaedon Avouris
1/F Noise In Carbon Nanotube Devices - On The Impact Of Contacts And Device Geometry, Joerg Appenzeller, Yu-Ming Lin, Joachim Knoch, Zhihong Chen, Phaedon Avouris
Other Nanotechnology Publications
We report on the 1/f noise in various ballistic carbon nanotube devices. A common means to characterize the quality of a transistor in terms of noise is to evaluate the ratio of the noise amplitude A and the sample resistance R. By contacting semiconducting tubes with different metal electrodes we are able to show that a small A/R value by itself is no indication of a suitable metal/tube combination for logic applications. We discuss how current in a nanotube transistor is determined by the injection of carriers at the electrode/nanotube interface, while at the same time excess noise is related …
Improved Carrier Injection In Ultrathin-Body Soi Schottky-Barrier Mosfets, M Zhang, Joachim Knoch, Joerg Appenzeller, S Mantl
Improved Carrier Injection In Ultrathin-Body Soi Schottky-Barrier Mosfets, M Zhang, Joachim Knoch, Joerg Appenzeller, S Mantl
Other Nanotechnology Publications
The impact of the gate oxide and the silicon-on-insulator (SOI) body thickness on the electrical performance of SOI Schottky-barrier (SB) MOSFETs with fully nickel silicided source and drain contacts is experimentally investigated. The subthreshold swing S is extracted from the experimental data and serves as a measure for the carrier injection through the Sills. It is shown that decreasing the gate oxide and body thickness allows to strongly increase the carrier injection and hence, a significantly improved ON-state of SB-MOSFETs can be obtained.
Hyperthermic Effects Of Gold Nanorods On Tumor Cells, Terry B. Huff, Ling Tong, Matthew N. Hansen, Ji-Xin Cheng, Alexander Wei
Hyperthermic Effects Of Gold Nanorods On Tumor Cells, Terry B. Huff, Ling Tong, Matthew N. Hansen, Ji-Xin Cheng, Alexander Wei
Other Nanotechnology Publications
Plasmon-resonant gold nanorods, which have large absorption cross sections at near-infrared frequencies, are excellent candidates as multifunctional agents for image-guided therapies based on localized hyperthermia. The controlled modification of the surface chemistry of the nanorods is of critical importance, as issues of cell-specific targeting and nonspecific uptake must be addressed prior to clinical evaluation. Nanorods coated with cetyltrimethylammonium bromide (a cationic surfactant used in nanorod synthesis) are internalized within hours into KB cells by a nonspecific uptake pathway, whereas the careful removal of cetyltrimethylammonium bromide from nanorods functionalized with folate results in their accumulation on the cell surface over the …