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Full-Text Articles in Nanoscience and Nanotechnology
Application Of Nanoparticles In Photodynamic Therapy And Increased Endothelial Permeability By Nanoparticle-Induced Activation Of Trpv4: Towards Improved Understanding Of Nanomedicine, Jaspreet Singh Nagi
Application Of Nanoparticles In Photodynamic Therapy And Increased Endothelial Permeability By Nanoparticle-Induced Activation Of Trpv4: Towards Improved Understanding Of Nanomedicine, Jaspreet Singh Nagi
Graduate College Dissertations and Theses
Nanotechnology holds great promise in biomedicine towards new diagnostics, new therapies, and improved patient outcomes. This work explores both the application of a novel nanoparticle in an established field of cancer treatment as well as an investigation of the human health implications of nanoparticles in intravenous applications. First, novel dye-linked zinc oxide nanoparticles (NPs) were investigated for use as photosensitizers (PS) for photodynamic therapy (PDT) due to their excellent thermal- and photo-stability. To overcome the limitations of current cancer treatments, we investigated the effectiveness of ZnO-Dye 847 NPs as a near infrared (NIR) PS in PDT. The NPs were surface …