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Full-Text Articles in Nanoscience and Nanotechnology
Redox-Dependent Calcium-Mediated Signaling Networks That Control The Senescence-Associated Secretory Phenotype, Akshaya Chandrasekaran
Redox-Dependent Calcium-Mediated Signaling Networks That Control The Senescence-Associated Secretory Phenotype, Akshaya Chandrasekaran
Legacy Theses & Dissertations (2009 - 2024)
Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential. While senescent cells have lost the ability to divide, they remain metabolically active and adapt a deleterious senescence associated secretory phenotype (SASP) central to the progression of several age-associated disease pathologies. The SASP is mechanistically regulated by the pro-inflammatory cytokine interleukin-1 alpha (IL-1α) whose expression and activity is responsive to the senescence associated (SA) oxidant production and the accompanying disruption of calcium (Ca2+) homeostasis. Using primary IMR-90 human fetal lung fibroblasts as a model of replicative senescence, we explored the molecular underpinnings driving Ca2+ …
Impedance Biosensors And Deep Crater Salivary Gland Scaffolds For Tissue Engineering, Robert Arthur Schramm
Impedance Biosensors And Deep Crater Salivary Gland Scaffolds For Tissue Engineering, Robert Arthur Schramm
Legacy Theses & Dissertations (2009 - 2024)
The salivary gland is a complex, branching organ whose primary biological function is the production of the fluid critical to alimentary function and the lubrication and maintenance of the oral cavity, saliva. The most frequent disruption of the salivary organ system is one in which the rate of supply of saliva into the oral cavity is diminished, and this may vary from a minor reduction, to near cessation. Regenerative medicine is a field which seeks to find ways to overcome the symptoms of organ malfunction or damage by inducing regrowth, repair and replacement of partial or whole organ function. Historically, …