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LABEL-FREE DETECTION; NUCLEIC-ACID; SURFACE; HYBRIDIZATION; MONOLAYERS; PROTEIN; GOLD; SEMICONDUCTORS; NANOWIRES; SUBSTRATE
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Full-Text Articles in Nanoscience and Nanotechnology
Dna Immobilization On Gap(100) Investigated By Kelvin Probe Force Microscopy, David Richards, Dmitry Zemlyanov, Rafay Asrar, Yena Chokshi, Emily Cook, Thomas Hinton, Xinran Lu, Viet Nguyen, Neil Patel, Jonathan Usher, Sriram Vaidyanathan, David Yeung, Albena Ivanisevic
Dna Immobilization On Gap(100) Investigated By Kelvin Probe Force Microscopy, David Richards, Dmitry Zemlyanov, Rafay Asrar, Yena Chokshi, Emily Cook, Thomas Hinton, Xinran Lu, Viet Nguyen, Neil Patel, Jonathan Usher, Sriram Vaidyanathan, David Yeung, Albena Ivanisevic
Dmitry Yurievich Zemlyanov
Understanding changes in the properties of semiconductor materials after immobilization of biomolecules on the surface is essential for the fabrication of well-tuned and programmable devices. The work examines changes in the properties of gallium phosphide (GaP) after modification with an organic linker, a single stranded DNA, and its complementary strand. We investigated changes in surface potential with Kelvin probe force microscopy (KPFM). Analysis revealed that a more ordered adlayer of ssDNA was present when a lower concentration of linker molecule was used. KPFM data combined with coverage data obtained from X-ray photoelectron spectroscopy (XPS) further confirmed this result. Successful hybridization …