Nanoscience and Nanotechnology Commons^™

Phase-Changing Nanodroplets As Nanotheranostic Platform For Combination Cancer Therapy, Catalina-Paula Spatarelu

Dartmouth College Ph.D Dissertations

Cancer is a cluster of diseases, and 1.8 million Americans are newly diagnosed each year. Treatment issues such as drug instability, the occurrence of severe side effects, as well as resistance make the need for solutions to improve conventional methods, like chemotherapy, apparent. Nano-sized drug-delivery platforms, particles loaded with therapeutic molecules that escape the immune system clearance and accumulate at the tumor site, were proposed as one of these solutions. Despite the expansion of the field, several aspects still need to be addressed: inconsistent delivery of the drugs, inability of measuring the effective dose being delivered to the tumor, lack …

Microwave And Ultrasonic Assisted Synthesis Of Zeolites From Coal Fly Ash In Batch And Circulating Batch Operation, Tahani Hassn Aldahri

Electronic Thesis and Dissertation Repository

This research was focused on the production of zeolites from CFA throughutilizing ultrasound and microwave power. The initial conventional heating process of 6 h prior to microwave irradiation for samples with high solid-to-liquid (S/L) ratio (CFA mass/ NaOH solution volume) led to a higher yield of zeolite and decreased the synthesis time and consumption of energy,while keeping the high quality of the synthesized zeolite intact. The crystal growth of the nuclei generated over 6 h of conventional hydrothermal treatment was enhanced by the post-microwave heating. Ultrasound-assisted zeolitizationCFA was also applied in this research.

When ultrasound energy was applied after hydrothermal …

The Effectiveness Of Localized Ultrasound And Aptamer Surface Modification On Nanoemulsions For Drug Delivery To Spheroids., Daniel A. Hodge

Electronic Theses and Dissertations

Cancer is a group of diseases that affects 1.6 million and kills nearly 600,000 Americans each year. The National Cancer Institute defines it as “diseases in which abnormal cells divide without control and can invade nearby tissues” and it is often treated with one or more of the following: chemotherapy, radiation, surgery. The expense for these treatments is expected to rise to $156 billion by 2020. Localized delivery can improve effectiveness and cancer survival rates, decrease the cost of treatment, and decrease the side effects of chemotherapy. This paper addresses models for this localized delivery through nanoemulsions. Nanoemulsions are a …