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Full-Text Articles in Nanoscience and Nanotechnology
Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski
Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski
Department of Mechanical and Materials Engineering: Faculty Publications
In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D …
Large-Scale Synthesis Of Compressible And Re-Expandable Three-Dimensional Nanofiber Matrices, Alec Mccarthy, Lorenzo Saldana, Daniel Mcgoldrick, Johnson V. John, Mitchell Kuss, Shixuan Chen, Bin Duan, Mark A. Carlson, Jingwei Xie
Large-Scale Synthesis Of Compressible And Re-Expandable Three-Dimensional Nanofiber Matrices, Alec Mccarthy, Lorenzo Saldana, Daniel Mcgoldrick, Johnson V. John, Mitchell Kuss, Shixuan Chen, Bin Duan, Mark A. Carlson, Jingwei Xie
Department of Mechanical and Materials Engineering: Faculty Publications
Due to their biomimetic properties, electrospun nanofibers have shown great potential in many biomedical fields. However, traditionally-produced nanofibers are typically two-dimensional (2D) membranes limiting their applications. Herein, we report a large-scale synthesis of compressible and reexpandable three-dimensional (3D) nanofiber matrices for potential biomedical applications. The reproducible mass production of such matrices is achieved using a multiple-emitter electrospinning machine with a controlled environment (e.g., temperature, humidity, and air flow rate) followed by an innovative gas-foaming expansion. The modified 20-emitter circular array with 3D-printed needle caps is capable of maintaining stable Taylor cones under extremely high flow rates. The introduction of such …
Molecular Combing Of Dna Nanofibers And Comparison To Electrospinning, Tanner L. Buresh
Molecular Combing Of Dna Nanofibers And Comparison To Electrospinning, Tanner L. Buresh
UCARE Research Products
The goal of these experiments was to create DNA nanofibers through the method of molecular combing (MC) and then compare the MC fibers to fibers created with electrospinning (ES). The experiment was designed and initial samples were created. After confirming that the method would succeed in creating DNA fibers, several parametric studies were performed in order to optimize the experiment and create the most uniform fibers possible. The parametric studies were done on the following variables: substrate material, pH level of DNA solution, and DNA solution concentration. After completion of all experiments, it was determined that although fibers could be …
A Comparative Study Of Polyurethane Nanofibers With Different Patterns And Its Analogous Nanofibers Containing Mwcnts, Javier Macossay-Torres, Faheem A. Sheikh, Hassan Ahmad, Hern Kim, Gary L. Bowlin
A Comparative Study Of Polyurethane Nanofibers With Different Patterns And Its Analogous Nanofibers Containing Mwcnts, Javier Macossay-Torres, Faheem A. Sheikh, Hassan Ahmad, Hern Kim, Gary L. Bowlin
Chemistry Faculty Publications and Presentations
Tissue engineering is a multidisciplinary field that has evolved in various dimensions in recent years. One of the main aspects in this field is the proper adjustment and final compatibility of implants at the target site of surgery. For this purpose, it is desired to have the materials fabricated at the nanometer scale, since these dimensions will ultimately accelerate the fixation of implants at the cellular level. In this study, electrospun polyurethane nanofibers and their analogous nanofibers containing MWCNTs are introduced for tissue engineering applications. Since MWCNTs agglomerate to form bundles, a high intensity sonication procedure was used to disperse …
Imaging, Spectroscopy, Mechanical, Alignment And Biocompatibility Studies Of Electrospun Medical Grade Polyurethane (Carbothane™ 3575a) Nanofibers And Composite Nanofibers Containing Multiwalled Carbon Nanotubes, Faheem A. Sheikh, Javier Macossay-Torres, Travis Cantu, Xujun Zhang, M. Shamshi Hassan, M. Esther Salinas, Chakavak S. Farhangi, Hassan Ahmad, Hern Kim, Gary L. Bowlin
Imaging, Spectroscopy, Mechanical, Alignment And Biocompatibility Studies Of Electrospun Medical Grade Polyurethane (Carbothane™ 3575a) Nanofibers And Composite Nanofibers Containing Multiwalled Carbon Nanotubes, Faheem A. Sheikh, Javier Macossay-Torres, Travis Cantu, Xujun Zhang, M. Shamshi Hassan, M. Esther Salinas, Chakavak S. Farhangi, Hassan Ahmad, Hern Kim, Gary L. Bowlin
Chemistry Faculty Publications and Presentations
In the present study, we discuss the electrospinning of medical grade polyurethane (Carbothane™ 3575A) nanofibers containing multi-walled-carbon-nanotubes (MWCNTs). A simple method that does not depend on additional foreign chemicals has been employed to disperse MWCNTs through high intensity sonication. Typically, a polymer solution consisting of polymer/MWCNTs has been electrospun to form nanofibers. Physiochemical aspects of prepared nanofibers were evaluated by SEM, TEM, FT-IR and Raman spectroscopy, confirming nanofibers containing MWCNTs. The biocompatibility and cell attachment of the produced nanofiber mats were investigated while culturing them in the presence of NIH 3T3 fibroblasts. The results from these tests indicated non-toxic behavior …
Imaging, Spectroscopic, Mechanical And Biocompatibility Studies Of Electrospun Tecoflex® Eg 80a Nanofibers And Composites Thereof Containing Multiwalled Carbon Nanotubes, Javier Macossay-Torres, Faheem A. Sheikh, Travis Cantu, Thomas Eubanks, M. Esther Salinas, Chakavak S. Farhangi, Hassan Ahmad, M. Shamshi Hassan, Myung-Seob Khil, Shivani K. Maffi, Hern Kim, Gary L. Bowlin
Imaging, Spectroscopic, Mechanical And Biocompatibility Studies Of Electrospun Tecoflex® Eg 80a Nanofibers And Composites Thereof Containing Multiwalled Carbon Nanotubes, Javier Macossay-Torres, Faheem A. Sheikh, Travis Cantu, Thomas Eubanks, M. Esther Salinas, Chakavak S. Farhangi, Hassan Ahmad, M. Shamshi Hassan, Myung-Seob Khil, Shivani K. Maffi, Hern Kim, Gary L. Bowlin
Chemistry Faculty Publications and Presentations
The present study discusses the design, development and characterization of electrospun Tecoflex® EG 80A class of polyurethane nanofibers and the incorporation of multiwalled carbon nanotubes (MWCNTs) to these materials. Scanning electron microscopy results confirmed the presence of polymer nanofibers, which showed a decrease in fiber diameter at 0.5% wt. and 1% wt. MWCNTs loadings, while transmission electron microscopy showed evidence of the MWCNTs embedded within the polymer matrix. The fourier transform infrared spectroscopy and Raman spectroscopy were used to elucidate the polymer-MWCNTs intermolecular interactions, indicating that the C-N and N-H bonds in polyurethanes are responsible for the interactions with MWCNTs. …
Biodegradable Electrospun Nanofibers Coated With Platelet-Rich Plasma For Cell Adhesion And Proliferation, Luis Diaz-Gomez, Carmen Alvarez-Lorenzo, Angel Concheiro, Maite Silva, Fernando Dominguez, Faheem A. Sheikh, Travis Cantu, Raj Desai, Vanessa L. Garcia, Javier Macossay-Torres
Biodegradable Electrospun Nanofibers Coated With Platelet-Rich Plasma For Cell Adhesion And Proliferation, Luis Diaz-Gomez, Carmen Alvarez-Lorenzo, Angel Concheiro, Maite Silva, Fernando Dominguez, Faheem A. Sheikh, Travis Cantu, Raj Desai, Vanessa L. Garcia, Javier Macossay-Torres
Chemistry Faculty Publications and Presentations
Biodegradable electrospun poly(ε-caprolactone) (PCL) scaffolds were coated with platelet-rich plasma (PRP) to improve cell adhesion and proliferation. PRP was obtained from human buffy coat, and tested on human adipose-derived mesenchymal stem cells (MSC) to confirm cell proliferation and cytocompatibility. Then, PRP was adsorbed on the PCL scaffolds via lyophilization, which resulted in uniform sponge-like coating of 2.85 (s.d. 0.14) mg/mg. The scaffolds were evaluated regarding mechanical properties (Young’s modulus, tensile stress and tensile strain), sustained release of total protein and growth factors (PDGF-BB, TGF-β1 and VEGF), and hemocompatibility. MSC seeded on the PRP-PCL nanofibers showed an increased adhesion and proliferation …
Experimental Study Of Nanofiber Production Through Forcespinning, Simon Padron, Arturo Fuentes, Dumitru Caruntu, Karen Lozano
Experimental Study Of Nanofiber Production Through Forcespinning, Simon Padron, Arturo Fuentes, Dumitru Caruntu, Karen Lozano
Mechanical Engineering Faculty Publications and Presentations
A newly developed method of producing nanofibers, called forcespinning, has proven to be a viable alternative to mass produce nanofibers. Unlike electrospinning, the most common method currently being employed (which draws fibers through the use of electrostatic force), forcespinning utilizes centrifugal forces which allow for a host of new materials to be processed into nanofibers (given that electric fields are not required) while also providing a significant increase in yield and ease of production. This work presents a detailed explanation of the fiber formation process. The study is conducted using high speed photography to capture the jet initiation process at …
Fabrication Of Poly(Vinylidene Fluoride) (Pvdf) Nanofibers Containing Nickel Nanoparticles As Future Energy Server Materials, Faheem A. Sheikh, Travis Cantu, Javier Macossay-Torres, Hern Kim
Fabrication Of Poly(Vinylidene Fluoride) (Pvdf) Nanofibers Containing Nickel Nanoparticles As Future Energy Server Materials, Faheem A. Sheikh, Travis Cantu, Javier Macossay-Torres, Hern Kim
Chemistry Faculty Publications and Presentations
In the present study, we introduce Poly(vinylidene fluoride) (PVDF) nanofibers containing nickel (Ni) nanoparticles (NPs) as a result of an electrospinning. Typically, a colloidal solution consisting of PVDF/Ni NPs was prepared to produce nanofibers embedded with solid NPs by electrospinning process. The resultant nanostructures were studied by SEM analyses, which confirmed well oriented nanofibers and good dispersion of Ni NPs over them. The XRD results demonstrated well crystalline feature of PVDF and Ni in the obtained nanostructures. Physiochemical aspects of prepared nano-structures were characterized for TEM which confirmed nanofibers were welloriented and had good dispersion of Ni NPs. Furthermore, the …
Microscopic And Spectroscopic Studies Of Thermally Enhanced Electrospun Pmma Micro- And Nanofibers, Sean Pelfrey, Travis Cantu, Michael R. Papantonakis, Duane L. Simonson, R. Andrew Mcgill, Javier Macossay-Torres
Microscopic And Spectroscopic Studies Of Thermally Enhanced Electrospun Pmma Micro- And Nanofibers, Sean Pelfrey, Travis Cantu, Michael R. Papantonakis, Duane L. Simonson, R. Andrew Mcgill, Javier Macossay-Torres
Chemistry Faculty Publications and Presentations
Carbon nanofibers (CNFs) have been incorporated into poly(methyl methacrylate) (PMMA) through electrospinning. The resulting micro- and nanofibers have been characterized by Scanning Electron Microscopy (SEM), which confirmed fiber formation and demonstrated a core-sheath structure of the PMMA fibers. Thermogravimetric Analysis (TGA) was used to obtain the thermal properties of the materials, indicating an enhancement in the thermal properties of the composite fibers. In addition, Fourier Transform Infrared Spectroscopy (FTIR) was utilized to investigate the interactions of PMMA micro- and nanofibers with CNFs, demonstrating the preferred sites of intermolecular interactions between the polymer matrix and the filler.