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Evaluation Of Silver Nanoparticle Encapsulation In Dppc-Based Liposome By Different Methods For Enhanced Cytotoxicity, Azeez O. Yusef, Alan Casey
Evaluation Of Silver Nanoparticle Encapsulation In Dppc-Based Liposome By Different Methods For Enhanced Cytotoxicity, Azeez O. Yusef, Alan Casey
Articles
Here we carried out a comparative study on two cost and time effective methods of encapsulating silver nanoparticles (AgNP) in dipalmitoyl-phosphatidyl choline (DPPC)/cholesterol-based liposome to enhance nanoparticle cytotoxicity, and evaluated the effect of this on a blood cell line (THP1 monocytes) often involved in uptake of nanoparticles during human exposure. DLS and Zeta potential analyses over a 6-months period showed the extruded Lipo-AgNP (Ex-Lipo-AgNP) exhibited more stable characteristics when compared with the probe-sonicated Lipo-AgNP (PB-Lipo-AgNP). SEM microscopy indicated agglomeration of the PB-Lipo-AgNP which was not observed in Ex-Lipo-AgNP. Ex-Lipo-AgNP also exhibited higher temperature-dependent stability with 35.3% reduction in size from …