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Physiologically-Based Pharmacokinetics Modeling Of Colloidal Nanoparticles, Anh-Dung Le

Nanoscience and Microsystems ETDs

Physiologically-based Pharmacokinetics (PBPK) modeling—a mechanistic mathematical tool to predict biodistribution to inform drug development, requires knowledge of the physico-chemical properties of the drug in question as well as the anatomy and physiology of the organism. Unlike with molecular drugs, nanoparticle parameters often need to be estimated by fitting models to time-course data, which can result in large uncertainties in parameter estimates due to a high-dimensional parameter space. Our research addresses this challenge by offering a path to parameter insights using global sensitivity analysis. The first chapter is an overview of the PBPK model structure and mathematical framework used in our …