Nanoscience and Nanotechnology Commons^™

Controllable Surface Expression Of Bioactive Peptides Incorporated Into A Silica Thin Film Matrix, Sabrina Jedlicka, Jenna Rickus, Dmitry Zemlyanov

Dmitry Yurievich Zemlyanov

Mammalian cell culture platforms often require biomolecular modification to enhance cell adhesion and proliferation, Often, these modifications are performed using self-assembled monolayers or whole protein coatings, Such its collagen. These protocols are inherently useful but generally suffer from repeatability. Undesirable conditions during self-assembly can lead to complications in the surface presentation of the biological ligands. Whole proteins are often unstable and derived from animal sources, making them less attractive for tissue engineering applications. As the biological effect of the material often depends strongly on the concentration of the integrated ligand(s), any complication due to synthesis or stability can lead to …