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Role Of Group Ii Metabotropic Glutamate Receptor Subtype 2 (Mglur2) In Appetitive And Consummatory Aspects Of Ethanol Reinforcement, Kyle Allyson Windisch Oct 2014

Role Of Group Ii Metabotropic Glutamate Receptor Subtype 2 (Mglur2) In Appetitive And Consummatory Aspects Of Ethanol Reinforcement, Kyle Allyson Windisch

Open Access Dissertations

Background: Group II metabotropic glutamate receptors (mGluR2/3) are predominately presynaptically located Gi/o coupled receptors that are highly expressed in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in regulating ethanol (EtOH) consumption and seeking following extinction (Backstrom and Hyytia, 2005; Kufahl, et al., 2011). The sipper tube model, which allows for procedural separation of seeking and consumption, was used to further clarify the role of mGluR2/3 in EtOH-seeking and consumption. The non-selective group II mGluR agonist LY379268 (LY37) and selective mGluR2 positive allosteric modulator (PAM) BINA were used to determine the …


Connecting Research On Social Issues In Nanotechnology: The Center For Nanotechnology In Society At Arizona State University, Jan Youtie, Philip Shapira Jan 2014

Connecting Research On Social Issues In Nanotechnology: The Center For Nanotechnology In Society At Arizona State University, Jan Youtie, Philip Shapira

Philip Shapira

Central to the emergence of new research topics is the creation of a research network. This paper looks at the creation of a network of researchers of social issues in nanotechnology and the role of the Center for Nanotechnology in Society at Arizona State University (CNS-ASU) in the creation of this network. While there has been US investment in societal research on nanotechnology, a debate exists about the extent to which a research community has been created through these investments. This paper uses three approaches to examine the extent to which CNS-ASU is associated with the development of a research …