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Full-Text Articles in Nanoscience and Nanotechnology

A Multi-Material Platform For Imaging Of Single Cell-Cell Junctions Under Tensile Load Fabricated With Two-Photon Polymerization, Jordan Rosenbohm, Grayson Minnick, Bahareh Tajvidi Safa, Amir M. Esfahani, Xiaowei Jin, Haiwei Zhai, Nickolay V. Lavrik, Ruiguo Yang May 2024

A Multi-Material Platform For Imaging Of Single Cell-Cell Junctions Under Tensile Load Fabricated With Two-Photon Polymerization, Jordan Rosenbohm, Grayson Minnick, Bahareh Tajvidi Safa, Amir M. Esfahani, Xiaowei Jin, Haiwei Zhai, Nickolay V. Lavrik, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

We previously reported a single-cell adhesion micro tensile tester (SCAμTT) fabricated from IP-S photoresin with two-photon polymerization (TPP) for investigating the mechanics of a single cell-cell junction under defined tensile loading. A major limitation of the platform is the autofluorescence of IP-S, the photoresin for TPP fabrication, which significantly increases background signal and makes fluorescent imaging of stretched cells difficult. In this study, we report the design and fabrication of a new SCAμTT platform that mitigates autofluorescence and demonstrate its capability in imaging a single cell pair as its mutual junction is stretched. By employing a two-material design using IP-S …


Injectable And Rapidly Expandable Thrombin-Decorated Cryogels Achieve Rapid Hemostasis And High Survival Rates In A Swine Model Of Lethal Junctional Hemorrhage, Syed Muntazir Andrabi, S.M. Shatil Shahriar, Al-Murtadha Al-Gahmi, Benjamin L. Wilczewski, Mark A. Carlson, Jingwei Xie Apr 2024

Injectable And Rapidly Expandable Thrombin-Decorated Cryogels Achieve Rapid Hemostasis And High Survival Rates In A Swine Model Of Lethal Junctional Hemorrhage, Syed Muntazir Andrabi, S.M. Shatil Shahriar, Al-Murtadha Al-Gahmi, Benjamin L. Wilczewski, Mark A. Carlson, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough to get them to the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide and thrombin (AT cryogels) created by cryo-polymerization for the efficient management of lethal junctional hemorrhage in swine. The produced cryogels have small pore sizes and highly interconnected porous architecture with robust mechanical strength. The cryogels exhibit rapid shape memory properties and prove to be resilient against fatigue. These cryogels also show high water/blood absorption capacity, fast blood clotting effect, and enhanced adhesion of red blood cells and …


Copper−Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial And Angiogenic Properties, Anik Karan, Navatha S. Polavaram, Margarita Darder, Yajuan Su, Syed Muntazir Andrabi, S M Shatil Shahriar, Johnson V. John, Zeyu Luo, Mark A. Decoster, Yu Shrike Zhang, Jingwei Xie Feb 2024

Copper−Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial And Angiogenic Properties, Anik Karan, Navatha S. Polavaram, Margarita Darder, Yajuan Su, Syed Muntazir Andrabi, S M Shatil Shahriar, Johnson V. John, Zeyu Luo, Mark A. Decoster, Yu Shrike Zhang, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Copper−cystine-based high aspect ratio structures (CuHARS) possess exceptional physical and chemical properties and exhibit remarkable biodegradability in human physiological conditions. Extensive testing has confirmed the biocompatibility and biodegradability of CuHARS under diverse biological conditions, making them a viable source of essential Cu2+. These ions are vital for catalyzing the production of nitric oxide (NO) from the decomposition of Snitrosothiols (RSNOs) found in human blood. The ability of CuHARS to act as a Cu2+ donor under specific concentrations has been demonstrated in this study, resulting in the generation of elevated levels of NO. Consequently, this dual function makes …


Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi Jan 2024

Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesized that implant configuration and mechanical interactions with the post-surgical lens capsule play a key role in determining long-term fibrotic remodeling.

Methods: We developed the first finite element-growth and remodeling (FE-G&R) model of the post-surgical lens capsule to evaluate how implantation of an IOL with and without a capsular tension ring (CTR) impacted evolving lens capsule mechanics and associated fibrosis over …


Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan Jan 2024

Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

The administration of therapeutics to peripheral nerve tissue is challenging due to the complexities of peripheral neuroanatomy and the limitations imposed by the blood–nerve barrier (BNB). Therefore, there is a pressing need to enhance delivery effectiveness and implement targeted delivery methods. Recently, erythrocyte-derived exosomes (Exos) have gained widespread attention as biocompatible vehicles for therapeutics in clinical applications. However, engineering targeted Exos for the peripheral nervous system (PNS) is still challenging. This study aims to develop a targeted Exo delivery system specifically designed for presynaptic terminals of peripheral nerve tissue. The clostridium neurotoxin, tetanus toxin-C fragment (TTC), was tethered to the …


Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim Jan 2024

Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

While yes-associated protein (YAP) is now recognized as a potent mechanosensitive transcriptional regulator to affect cell growth and differentiation including the osteogenic transcription of mesenchymal stem cells (MSCs), most studies have reported the YAP mechanosensing of static mechanophysical cues such as substrate stiffness. We tested MSC response to dynamic loading, i.e., cyclic mechanical stretching, and assessed YAP mechanosensing and resultant MSC osteogenesis. We showed that cyclic stretching at 10% strain and 1 Hz frequency triggered YAP nuclear import in MSCs. YAP phosphorylation at S127 and S397, which is required for YAP cytoplasmic retention, was suppressed by cyclic stretch. We also …


Exploring Regular And Turbulent Flow States In Active Nematic Channel Flow Via Exact Coherent Structures And Their Invariant Manifolds, Caleb G. Wagner, Rumayel H. Pallock, Jae Sung Park, Michael M. Norton, Piyush Grover Dec 2023

Exploring Regular And Turbulent Flow States In Active Nematic Channel Flow Via Exact Coherent Structures And Their Invariant Manifolds, Caleb G. Wagner, Rumayel H. Pallock, Jae Sung Park, Michael M. Norton, Piyush Grover

Department of Mechanical and Materials Engineering: Faculty Publications

This work is a unified study of stable and unstable steady states of 2D active nematic channel flow using the framework of Exact Coherent Structures (ECSs). ECSs are stationary, periodic, quasiperiodic, or traveling wave solutions of the governing equations that, together with their invariant manifolds, organize the dynamics of nonlinear continuum systems. We extend our earlier work on ECSs in the preturbulent regime by performing a comprehensive study of stable and unstable ECSs for a wide range of activity values spanning the preturbulent and turbulent regimes. In the weakly turbulent regime, we compute more than 200 unstable ECSs that coexist …


What Does It Mean To Be “Prepared For Work”? Perceptions Of New Engineers, Jessica R. Deters, Marie C. Paretti, Logan A. Perry, Robin Ott Nov 2023

What Does It Mean To Be “Prepared For Work”? Perceptions Of New Engineers, Jessica R. Deters, Marie C. Paretti, Logan A. Perry, Robin Ott

Department of Mechanical and Materials Engineering: Faculty Publications

Background: Engineering education seeks to prepare students for engineering practice, but the concept of preparedness is often ill-defined. Moreover, findings from studies of different populations or in different contexts vary regarding how well new graduates are prepared. These variations, coupled with the lack of clarity, suggest the need to better understand what it means to be prepared for engineering work.

Purpose: This study contributes to research on workplace preparation by exploring how new graduates describe being prepared for engineering work.

Method: Applying secondary analysis to data from the multi-institution Capstone To Work (C2W) project, we used thematic …


A Review On The Coalescence Of Confined Drops With A Focus On Scaling Laws For The Growth Of The Liquid Bridge, Sangjin Ryu, Haipeng Zhang, Udochukwu John Anuta Oct 2023

A Review On The Coalescence Of Confined Drops With A Focus On Scaling Laws For The Growth Of The Liquid Bridge, Sangjin Ryu, Haipeng Zhang, Udochukwu John Anuta

Department of Mechanical and Materials Engineering: Faculty Publications

The surface–tension-driven coalescence of drops has been extensively studied because of the omnipresence of the phenomenon and its significance in various natural and engineering systems. When two drops come into contact, a liquid bridge is formed between them and then grows in its lateral dimensions. As a result, the two drops merge to become a bigger drop. The growth dynamics of the bridge are governed by a balance between the driving force and the viscous and inertial resistances of involved liquids, and it is usually represented by power–law scaling relations on the temporal evolution of the bridge dimension. Such scaling …


Revealing Interface-Assisted Plastic Anisotropy Via In Situ Transmission Electron Microscopy Tension Of Lamellar Tial, Zhixiang Qi, Qi Zhu, Jian Wang, Yuede Cao, Fengrui Chen, Jiangwei Wang, Yang Chen, Gong Zheng, Guang Chen Oct 2023

Revealing Interface-Assisted Plastic Anisotropy Via In Situ Transmission Electron Microscopy Tension Of Lamellar Tial, Zhixiang Qi, Qi Zhu, Jian Wang, Yuede Cao, Fengrui Chen, Jiangwei Wang, Yang Chen, Gong Zheng, Guang Chen

Department of Mechanical and Materials Engineering: Faculty Publications

Assembling functional units into specific orientation organizations based on functional unit and organization (FUO) paradigm can maximize utilizing mechanical property anisotropy of lamellar-structured materials. However, the origin of their anisotropic deformation behaviors has not been clearly understood. Taking the fully lamellar γ-TiAl/ α2-Ti3Al dual-phase single crystal as an example, we decouple the interface functional units governed anisotropic plastic deformation through in situ transmission electron microscopy tensile testing and multiscale microstructural characterizations. The orientation organization-dependent slip continuity across the γ/α2 interface and interface strength play a determinant role in plastic anisotropy beyond intrinsic dislocation activities within …


Steerable Acoustically Powered Starfish-Inspired Microrobot, Cornel Dillinger, Justin Knipper, Nitesh Nama, Daniel Ahmed Oct 2023

Steerable Acoustically Powered Starfish-Inspired Microrobot, Cornel Dillinger, Justin Knipper, Nitesh Nama, Daniel Ahmed

Department of Mechanical and Materials Engineering: Faculty Publications

Soft polymeric microrobots that can be loaded with nanocargoes and driven via external field stimuli can provide innovative solutions in various fields, including precise microscale assembly, targeted therapeutics, microsurgery, and the capture and degradation of unwanted wastewater fragments. However, in aquatic environments, it remains challenging to operate with microrobotic devices due to the predominant viscous resistances and the robots’ limited actuation and sensing capabilities attributed to their miniaturization. The miniature size prevents the incorporation of onboard batteries that can provide sufficient power for propulsion and navigation, necessitating a wireless power supply. Current research examines untethered microrobot manipulation using external magnetic, …


Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery, Justin R. Brooks, Tyler C. Heiman, Sawyer R. Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, Ruiguo Yang Oct 2023

Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery, Justin R. Brooks, Tyler C. Heiman, Sawyer R. Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Porous substrate electroporation (PSEP) is a promising new method for delivering molecules such as proteins and nucleic acids into cells for biomedical research. Although many applications have been demonstrated, fundamentals of the PSEP delivery process are not yet well understood, partly because most PSEP studies rely solely on fluorescent imaging for evaluating delivery and quantifying successful outcomes. Although effective, only utilizing imaging alone limits our understanding of the intermediate processes leading to intracellular delivery. Since PSEP is an electrical process, electrical impedance measurements are a natural addition to fluorescent imaging for PSEP characterization. In this study, we developed an integrated …


Increased Ductility Of Ti-6al-4v By Interlayer Milling During Directed Energy Deposition, Rakeshkumar Karunakaran, Luz D. Sotelo, Hitarth Maharaja, Calsey Nez, Monsuru Ramoni, Scott Halliday, Sushil Mishra, Joseph A. Turner, Michael P. Sealy Oct 2023

Increased Ductility Of Ti-6al-4v By Interlayer Milling During Directed Energy Deposition, Rakeshkumar Karunakaran, Luz D. Sotelo, Hitarth Maharaja, Calsey Nez, Monsuru Ramoni, Scott Halliday, Sushil Mishra, Joseph A. Turner, Michael P. Sealy

Department of Mechanical and Materials Engineering: Faculty Publications

Additive manufacturing (AM) often results in high strength but poor ductility in titanium alloys. Hybrid AM is a solution capable of improving both ductility and strength. In this study, hybrid AM of Ti-6Al-4V was achieved by coupling directed energy deposition with interlayer machining. The microstructure, residual stress, and microhardness were examined to explain how interlayer machining caused a 63% improvement in ductility while retaining an equivalent strength to as-printed samples. Interlayer machining introduced recurrent interruptions in printing that allowed for slow cooling-induced coarsening of acicular α laths at the machined interfaces. The coarse α laths on the selectively machined layers …


Acoustophoresis Around An Elastic Scatterer In A Standing Wave Field, Khemraj Gautam Kshetri, Nitesh Nama Oct 2023

Acoustophoresis Around An Elastic Scatterer In A Standing Wave Field, Khemraj Gautam Kshetri, Nitesh Nama

Department of Mechanical and Materials Engineering: Faculty Publications

Acoustofluidic systems often employ prefabricated acoustic scatterers that perturb the imposed acoustic field to realize the acoustophoresis of immersed microparticles. We present a numerical study to investigate the timeaveraged streaming and radiation force fields around a scatterer. Based on the streaming and radiation force field, we obtain the trajectories of the immersed microparticles with varying sizes and identify a critical transition size at which the motion of immersed microparticles in the vicinity of a prefabricated scatterer shifts from being streaming dominated to radiation dominated. We consider a range of acoustic frequencies to reveal that the critical transition size decreases with …


Stomatal Opening Efficiency Is Controlled By Cell Wall Organization In Arabidopsis Thaliana, Sedighe Keynia, Leila Jaafar, You Zhou, Charles T. Anderson, Joseph A. Turner Sep 2023

Stomatal Opening Efficiency Is Controlled By Cell Wall Organization In Arabidopsis Thaliana, Sedighe Keynia, Leila Jaafar, You Zhou, Charles T. Anderson, Joseph A. Turner

Department of Mechanical and Materials Engineering: Faculty Publications

Stomatal function in plants is regulated by the nanoscale architecture of the cell wall and turgor pressure, which together control stomatal pore size to facilitate gas exchange and photosynthesis. The mechanical properties of the cell wall and cell geometry are critical determinants of stomatal dynamics. However, the specific biomechanical functions of wall constituents, for example, cellulose and pectins, and their impact on the work required to open or close the stomatal pore are unclear. Here, we use nanoindentation in normal and lateral directions, computational modeling, and microscopic imaging of cells from the model plant Arabidopsis thaliana to investigate the precise …


Twin-Solute, Twin-Dislocation And Twin-Twin Interactions In Magnesium, Materials Yue, Jian Wang, Jian-Feng Nie Jul 2023

Twin-Solute, Twin-Dislocation And Twin-Twin Interactions In Magnesium, Materials Yue, Jian Wang, Jian-Feng Nie

Department of Mechanical and Materials Engineering: Faculty Publications

Magnesium alloys have received considerable research interest due to their lightweight, high specific strength and excellent castability. However, their plastic deformation is more complicated compared to cubic materials, primarily because their low-symmetry hexagonal closepacked (hcp) crystal structure. Deformation twinning is a crucial plastic deformation mechanism in magnesium, and twins can affect the evolution of microstructure by interacting with other lattice defects, thereby affecting the mechanical properties. This paper provides a review of the interactions between deformation twins and lattice defects, such as solute atoms, dislocations and twins, in magnesium and its alloys. This review starts with interactions between twin boundaries …


Atomistic Simulations Of Twin Facets Associated With Three-Dimensional { []011 } Twins In Magnesium, Qiyu Zeng, Mingyu Gong, Houyu Ma, Yao Shen, Jian-Feng Nie, Jian Wang, Yue Liu Jul 2023

Atomistic Simulations Of Twin Facets Associated With Three-Dimensional { []011 } Twins In Magnesium, Qiyu Zeng, Mingyu Gong, Houyu Ma, Yao Shen, Jian-Feng Nie, Jian Wang, Yue Liu

Department of Mechanical and Materials Engineering: Faculty Publications

Twinning is a deformation mechanism that creates three-dimensional (3D) twin domains through the migration of twin facets. This occurs via the nucleation and glide of twinning disconnections (TDs), which can pile up to create twin facets. A comprehensive under- standing of twin facets associated with 3D twins, including their atomic structures and energies, is crucial for understanding deformation twinning. In this study, we propose a molecular statics/dynamics (MS/MD) approach to determine characteristic twin facets enclosing 3D non-equilibrium/equilibrium { [] 011 } twin domains, which has been much less studied than the counterpart { [] 012 } twin domains. The stability …


The Essential Work Of Fracture In Peridynamics, Christer Stenström, Kjell Eriksson, Florin Bobaru, Stefan Golling, Pär Jonsén Jul 2023

The Essential Work Of Fracture In Peridynamics, Christer Stenström, Kjell Eriksson, Florin Bobaru, Stefan Golling, Pär Jonsén

Department of Mechanical and Materials Engineering: Faculty Publications

In this work, the essential work of fracture (EWF) method is introduced for a peridynamic (PD) material model to characterize fracture toughness of ductile materials. First, an analytical derivation for the path-independence of the PD J -integral is provided. Thereafter, the classical J -integral and PD J-integral are computed on a number of analytical crack problems, for subsequent investigation on how it performs under large scale yielding of thin sheets. To represent a highly nonlinear elastic behavior, a new adaptive bond stiffness calibration and a modified bonddamage model with gradual softening are proposed. The model is employed for two …


Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski Jul 2023

Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski

Department of Mechanical and Materials Engineering: Faculty Publications

In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D …


Nitric Oxide: Physiological Functions, Delivery, And Biomedical Applications, Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie Jun 2023

Nitric Oxide: Physiological Functions, Delivery, And Biomedical Applications, Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its gaseous form, NO has a short half-life, and its physiology role is concentration dependent, often restricting its function to a target site. Providing NO from an external source is beneficial in promoting cellular functions and treatment of different pathological conditions. Hence, the multifaceted role of NO in physiology and pathology has garnered massive interest in developing strategies to deliver exogenous NO for the treatment of various regenerative and biomedical …


Design And Development Of Ultrabroadband, High-Gain, And High-Isolation Thz Mimo Antenna With A Complementary Split-Ring Resonator Metamaterial, Ammar Armghan, Khaled Aliqab, Meshari Alsharari, Osamah Alsalman, Juveriya Parmar, Shobhit K. Patel Jun 2023

Design And Development Of Ultrabroadband, High-Gain, And High-Isolation Thz Mimo Antenna With A Complementary Split-Ring Resonator Metamaterial, Ammar Armghan, Khaled Aliqab, Meshari Alsharari, Osamah Alsalman, Juveriya Parmar, Shobhit K. Patel

Department of Mechanical and Materials Engineering: Faculty Publications

The need for high-speed communication has created a way to design THz antennas that operate at high frequencies, speeds, and data rates. In this manuscript, a THz MIMO antenna is designed using a metamaterial. The two-port antenna design proposed uses a complementary splitring resonator patch. The design results are also compared with a simple patch antenna to show the improvement. The design shows a better isolation of 50 dB. A broadband width of 8.3 THz is achieved using this complementary split-ring resonator design. The percentage bandwidth is 90%, showing an ultrabroadband response. The highest gain of 10.34 dB is achieved …


Restoration Of Normal Blood Flow In Atherosclerotic Arteries Promotes Plaque Stabilization, Morgan A. Schake, Ian Mccue, Evan T. Curtis, Thomas J. Ripperda Jr., Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi Jun 2023

Restoration Of Normal Blood Flow In Atherosclerotic Arteries Promotes Plaque Stabilization, Morgan A. Schake, Ian Mccue, Evan T. Curtis, Thomas J. Ripperda Jr., Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Blood flow is a key regulator of atherosclerosis. Disturbed blood flow promotes atherosclerotic plaque development, whereas normal blood flow protects against plaque development. We hypothesized that normal blood flow is also therapeutic, if it were able to be restored within atherosclerotic arteries. Apolipoprotein E-deficient (ApoE-/-) mice were initially instrumented with a blood flow-modifying cuff to induce plaque development and then five weeks later the cuffwas removed to allowrestoration of normal blood flow. Plaques in decuffed mice exhibited compositional changes that indicated increased stability compared to plaques in mice with the cuff maintained. The therapeutic benefit of decuffingwas comparable …


Exploring The Intersection Of Biology And Design For Product Innovations, Ajay P. Malshe, Salil Bapat, Kamlakar Rajurkar, Ang Ang, Jean-Marc Linares May 2023

Exploring The Intersection Of Biology And Design For Product Innovations, Ajay P. Malshe, Salil Bapat, Kamlakar Rajurkar, Ang Ang, Jean-Marc Linares

Department of Mechanical and Materials Engineering: Faculty Publications

Design, development, productization, and applications of advanced product concepts are pressing for higher multifunctionality, resilience, and maximization of available resources equitably to meet the growing and continuing demands of global customers. These demands have further accelerated during the recent COVID- 19 pandemic and are continuing to be a challenge. Engineering designs are one of the most effective ways to endow products with functions, resilience, and sustainability. Biology, through millions of years of evolution, has met these acute requirements under severe resource and environmental constraints. As the manufacturing of products is reaching the fundamental limits of raw materials, labor, and resource …


Self-Assembly Of Exfoliated Graphene Flakes As Anticorrosive Coatings For Additive Manufactured Steels, Kaleb Hood, Wen Qian, Yi Xia, Savannah Krupa, Annie Dao, Sarah Ahmed, Samuel Olson, Nam Nguyen, Joseph A. Turner, Jun Jiao May 2023

Self-Assembly Of Exfoliated Graphene Flakes As Anticorrosive Coatings For Additive Manufactured Steels, Kaleb Hood, Wen Qian, Yi Xia, Savannah Krupa, Annie Dao, Sarah Ahmed, Samuel Olson, Nam Nguyen, Joseph A. Turner, Jun Jiao

Department of Mechanical and Materials Engineering: Faculty Publications

This study demonstrates the feasibility of using liquid exfoliation of expandable graphite into multilayer exfoliated graphene flakes (EGFs) to form a self-assembled thin film on an air–water interface. The film can coat the surface of additive manufactured (AM) steel substrates to enhance surface properties, specifically AM 316 stainless-steel (AM316), AM 8620 steel (AM8620), and samples of the same alloys made by conventional manufacturing (CM) processes. Liquid exfoliation offers a high yield route for an EGF coating that can cover up to 95% of the sample surface with a single application. The thin, flexible EGFs can coat a rough AM metal …


Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu Apr 2023

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …


Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu Apr 2023

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …


Considering The Influence Of Coronary Motion On Artery‑Specific Biomechanics Using Fluid–Structure Interaction Simulation, Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil De Silva, Rob Krams Apr 2023

Considering The Influence Of Coronary Motion On Artery‑Specific Biomechanics Using Fluid–Structure Interaction Simulation, Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil De Silva, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

The endothelium in the coronary arteries is subject to wall shear stress and vessel wall strain, which influences the biology of the arterial wall. This study presents vessel-specific fluid–structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models are used to provide a more physiologically complete representation of vessel biomechanics, and have been extended to include coronary bending to investigate its effect on shear and strain. FSI both without- and with-bending resulted in significant changes in all computed shear stress metrics compared to CFD (p = 0.0001). Inclusion of bending within …


A Threshold Helium Leakage Detection Switch With Ultra Low Power Operation, Sulaiman Mohaidat, Fadi M. Alsaleem Apr 2023

A Threshold Helium Leakage Detection Switch With Ultra Low Power Operation, Sulaiman Mohaidat, Fadi M. Alsaleem

Department of Mechanical and Materials Engineering: Faculty Publications

Detecting helium leakage is important in many applications, such as in dry cask nuclear waste storage systems. This work develops a helium detection system based on the relative permittivity (dielectric constant) difference between air and helium. This difference changes the status of an electrostatic microelectromechanical system (MEMS) switch. The switch is a capacitive-based device and requires a very negligible amount of power. Exciting the switch’s electrical resonance enhances the MEMS switch sensitivity to detect low helium concentration. This work simulates two different MEMS switch configurations: a cantilever-based MEMS modeled as a single-degreefreedom model and a clamped-clamped beam MEMS molded using …


Crystalline–Amorphous Nanostructures: Microstructure, Property And Modelling, Binqiang Wei, Lin Li, Lin Shao, Jian Wang Apr 2023

Crystalline–Amorphous Nanostructures: Microstructure, Property And Modelling, Binqiang Wei, Lin Li, Lin Shao, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Crystalline metals generally exhibit good deformability but low strength and poor irradiation tolerance. Amorphous materials in general display poor deformability but high strength and good irradiation tolerance. Interestingly, refining characteristic size can enhance the flow strength of crystalline metals and the deformability of amorphous materials. Thus, crystalline–amorphous nanostructures can exhibit an enhanced strength and an improved plastic flow stability. In addition, high-density interfaces can trap radiation-induced defects and accommodate free volume fluctuation. In this article, we review crystalline–amorphous nanocomposites with characteristic microstructures including nanolaminates, core–shell microstructures, and crystalline/amorphous-based dual-phase nanocomposites. The focus is put on synthesis of characteristic microstructures, deformation …


Plasmon Enhanced Quantum Properties Of Single Photon Emitters With Hybrid Hexagonal Boron Nitride Silver Nanocube Systems, Mohammadjavad Dowran, Andrew Butler, Suvechhya Lamichhane, Adam Erickson, Ufuk Kilic, Sy_Hwang Liou, Christos Argyropoulos, A. Laraoui Apr 2023

Plasmon Enhanced Quantum Properties Of Single Photon Emitters With Hybrid Hexagonal Boron Nitride Silver Nanocube Systems, Mohammadjavad Dowran, Andrew Butler, Suvechhya Lamichhane, Adam Erickson, Ufuk Kilic, Sy_Hwang Liou, Christos Argyropoulos, A. Laraoui

Department of Mechanical and Materials Engineering: Faculty Publications

Hexagonal boron nitride (hBN) has emerged as a promising ultrathin host of single photon emitters (SPEs) with favorable quantum properties at room temperature, making it a highly desirable element for integrated quantum photonic networks. One major challenge of using these SPEs in such applications is their low quantum efficiency. Recent studies have reported an improvement in quantum efficiency by up to two orders of magnitude when integrating an ensemble of emitters such as boron vacancy defects in multilayered hBN flakes embedded within metallic nanocavities. However, these experiments have not been extended to SPEs and are mainly focused on multiphoton effects. …