Nanoscience and Nanotechnology Commons^™

System And Methods For Ventilation Through A Body Cavity, Mark A. Borden, Benjamin S. Terry

Department of Mechanical and Materials Engineering: Faculty Publications

A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles . Through circulation of oxygen microbubbles through the body cavity , oxygen and carbon dioxide exchange may occur . Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen - intake restricting injury and / or failure may be achieved through use of the invented system and methods .

Hemodynamics And Pathology Of An Enlarging Abdominal Aortic Aneurysm Model In Rabbits, Hongmei Chen, Yonghua Bi, Siyeong Yu, Linxia Gu, Xiaoyan Zhu, Xinwei Han

Department of Mechanical and Materials Engineering: Faculty Publications

Hemodynamics may play an essential role in the initiation and progression of abdominal aortic aneurysm (AAA). We aimed to study the mechanism of self-healing process by the changes of hemodynamics and pathology in an enlarging AAA in rabbits. Seventy-two rabbits were randomly divided into three groups. Rabbits underwent extrinsic coarctation and received a 10-minute elastase incubation in Group A and Group B. Absorbable suture used in Group A was terminated by balloon dilation at week 4. Diameter was measured after 1, 3, 5, and 15 weeks, computational fluid dynamics analysis was performed at week 3 and week 15. Rabbits were …

Techniques To Stimulate And Interrogate Cell–Cell Adhesion Mechanics, Ruiguo Yang, Joshua A. Broussard, Kathleen J. Green, Horacio D. Espinosa

Department of Mechanical and Materials Engineering: Faculty Publications

Cell–cell adhesions maintain the mechanical integrity of multicellular tissues and have recently been found to act as mechanotransducers, translating mechanical cues into biochemical signals. Mechanotransduction studies have primarily focused on focal adhesions, sites of cell-substrate attachment. These studies leverage technical advances in devices and systems interfacing with living cells through cell–extracellular matrix adhesions. As reports of aberrant signal transduction originating from mutations in cell–cell adhesion molecules are being increasingly associated with disease states, growing attention is being paid to this intercellular signaling hub. Along with this renewed focus, new requirements arise for the interrogation and stimulation of cell–cell adhesive junctions. …

Strong And Tough Continuous Nanofibers, Yuris Dzenis

Department of Mechanical and Materials Engineering: Faculty Publications

Amethod of fabricating a continuous nanofiber is described . The method includes preparing a solution of one or more polymers and one or more solvents and electrospinning the solution by discharging the solution through one or more liquid jets into an electric field to yield one or more continuous nanofibers . The electrospinning process ( i ) highly orients one or more polymer chains in the one or more continuous nanofibers along a fiber axis of the one or more continuous nanofibers , and ( ii ) suppresses polymer crystallization in the one or more continuous nanofibers . The one …

Near-Field Heat Transfer Enabled Nanothermomechanical Memory And Logic Devices, Sidy Ndao, Mahmoud Elzouka

Department of Mechanical and Materials Engineering: Faculty Publications

A thermomechanical memory / logic device is disclosed . In embodiments , the thermomechanical device includes a first thermally controlled terminal ( e . g . , hot terminal ) ; a second thermally controlled terminal ( e . g . , cool terminal / base ) ; a stem or other structure that can be thermally expanded connected to the cool terminal ; and a thermal conductive head coupled to the stem . The head can exchange heat with the hot terminal . The stem and head are between the first thermally controlled terminal and the second thermally controlled …

Smart Bandage For Monitoring And Treatment Of Chronic Wounds, Pooria Mostafalu, Ali Tamayol, Rahim Rahimi, Manuel Ochoa, Akbar Khalilpour, Gita Kiaee, Iman K. Yazdi, Sara Bagherifard, Mehmet R. Dokmeci, Babak Ziaie, Sameer R. Sonkusale, Ali Khademhosseini

Department of Mechanical and Materials Engineering: Faculty Publications

Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to …

Prevascularization Of 3d Printed Bone Scaffolds By Bioactive Hydrogels And Cell Co-Culture, Mitchell Kuss, Shaohua Wu, Ying Wang, Jason B. Untrauer, Wenlong Li, Jung Yul Lim, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

Vascularization is a fundamental prerequisite for large bone construct development and remains one of the main challenges of bone tissue engineering. Our current study presents the combination of 3D printing technique with a hydrogel-based prevascularization strategy to generate prevascularized bone constructs. Human adipose derived mesenchymal stem cells (ADMSC) and human umbilical vein endothelial cells (HUVEC) were encapsulated within our bioactive hydrogels, and the effects of culture conditions on in vitro vascularization were determined. We further generated composite constructs by forming 3D printed polycaprolactone/hydroxyapatite scaffolds coated with cell-laden hydrogels and determined how the co-culture affected vascularization and osteogenesis. It was demonstrated …

Migration Resistance Of Esophageal Stents: The Role Of Stent Design, Hozhabr Mozafari, Pengfei Dong, Shijia Zhao, Yonghua Bi, Xinwei Han, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Objective: Stenting is one of the major treatments for malignant esophageal cancer. However, stent migration compromises clinical outcomes. A flared end design of the stent diminishes its migration. The goal of this work is to quantitatively characterize stent migration to develop new strategies for better clinical outcomes.

Methods: An esophageal stent with flared ends and a straight counterpart were virtually deployed in an esophagus with asymmetric stricture using the finite element method. The resulted esophagus shape, wall stress, and migration resistance force of the stent were quantified and compared.

Results: The lumen gain for both the flared stent and the …

System And Method For Controlling Operations Of Air - Conditioning System, Mouhacine Benosman, Petros Boufounos, Boris Kramer, Piyush Grover

Department of Mechanical and Materials Engineering: Faculty Publications

A method controls an operation of an air - conditioning system generating airflow in a conditioned environment . The method updates a model of airflow dynamics connecting values of flow and temperature of air conditioned during the operation of the air - conditioning system . The model is updated interactively iteratively to reduce an error between values of the airflow determined according to the model and values of the airflow measured during the operation . Next , the method models the airflow using the updated model and controls the operation of the air - conditioning system using the model .

Concomitant Crystallization In Propylene/Ethylene Random Copolymer With Strong Flow At Elevated Temperatures, Lirong Zheng, Lucia Fernandez-Ballester, Gerrit W. M. Peters, Zhe Ma

Department of Mechanical and Materials Engineering: Faculty Publications

Flow-induced crystallization of α- and γ-phases was studied for a propylene/ethylene random copolymer with 3.4 mol % ethylene at two high temperatures of 132 and 142 °C by combining a pressure-driven slit flow device with real-time synchrotron wide-angle X-ray diffraction. At 132 °C, it was found that both α- and γ-phases were generated at shear stresses ranging from 0.091 to 0.110 MPa and that the γ-phase always appeared later than the α-phase. However, for 142 °C and the same stresses, only the α-phase formed. Only upon cooling the partially crystallized copolymer did the γ-phase emerge. The lack of γ-crystals obtained …

Rare Earth - Free Permanent Magnetic Material, Laura H. Lewis, Jeffrey E. Shield, Katayun Barmak Viziri

Department of Mechanical and Materials Engineering: Faculty Publications

The invention provides rare earth - free permanent magnetic materials and methods of making them . The materials can be used to produce magnetic structures for use in a wide variety of commercial applications , such as motors , generators , and other electromechanical and electronic devices . Magnets fabricated using the materials can be substituted for magnets requiring rare earth elements that are costly and in limited supply . The invention provides two different types of magnetic materials . The first type is based on an iron - nickel alloy that is doped with one or more doping elements …

Method Of Fabricating A Continuous Nanofiber, Yuris Dzenis

Department of Mechanical and Materials Engineering: Faculty Publications

A method of fabricating a continuous nanofiber is described . The method includes preparing a solution of one or more polymers and one or more solvents and electrospinning the solution by discharging the solution through one or more liquid jets into an electric field to yield one or more continuous nanofibers . The electrospinning process ( i ) highly orients one or more polymer chains in the one or more continuous nanofibers along a fiber axis of the one or more continuous nanofibers , and ( ii ) suppresses polymer crystallization in the one or more continuous nanofibers . The …

Method For Data - Driven Learning - Based Control Of Hvac Systems Using High - Dimensional Sensory Observations, Amir-Massoud Farahmand, Saleh Nabi, Piyush Grover, Daniel Nikolaev Nikovski

Department of Mechanical and Materials Engineering: Faculty Publications

A controller for controlling an operation of an air - conditioning system conditioning an indoor space includes a data input to receive state data of the space at multiple points in the space , a memory to store a code of a reinforcement learning algorithm and a history of the state data and a history of control commands having been applied to the air - conditioning system , wherein the history of the control commands is associated with the state data and history of rewards , a processor coupled to the memory determines a value function outputting a cumulative value …

The Effect Of Poly (Glycerol Sebacate) Incorporation Within Hybrid Chitin–Lignin Sol–Gel Nanofibrous Scaffolds, Tuerdimaimaiti Abudula, Lassaad Gzara, Giovanna Simonetti, Ahmed Alshahrie, Numan Salah, Pierfrancesco Morganti, Angelo Chianese, Afsoon Fallahi, Ali Tamayol, Sidi A. Bencherif, Adnan Memic

Department of Mechanical and Materials Engineering: Faculty Publications

Chitin and lignin primarily accumulate as bio-waste resulting from byproducts of crustacean crusts and plant biomass. Recently, their use has been proposed for diverse and unique bioengineering applications, amongst others. However, their weak mechanical properties need to be improved in order to facilitate their industrial utilization. In this paper, we fabricated hybrid fibers composed of a chitin–lignin (CL)-based sol–gel mixture and elastomeric poly (glycerol sebacate) (PGS) using a standard electrospinning approach. Obtained results showed that PGS could be coherently blended with the sol–gel mixture to form a nanofibrous scaffold exhibiting remarkable mechanical performance and improved antibacterial and antifungal activity. The …

The Positive Role Of Curcumin-Loaded Salmon Nanoliposomes On The Culture Of Primary Cortical Neurons, Mahmoud Hasan, Shahrzad Latifi, Cyril J.F. Kahn, Ali Tamayol, Rouhollah Habibey, Elodie Passeri, Michel Linder, Elmira Arab-Tehrany

Department of Mechanical and Materials Engineering: Faculty Publications

Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

Electroosmotic Flow Of Viscoelastic Fluid In A Nanoslit, Lanju Mei, Hongna Zhang, Hongxia Meng, Shizhi Qian

Mechanical & Aerospace Engineering Faculty Publications

The electroosmotic flow (EOF) of viscoelastic fluid in a long nanoslit is numerically studied to investigate the rheological property effect of Linear Phan-Thien-Tanner (LPTT) fluid on the fully developed EOF. The non-linear Poisson-Nernst-Planck equations governing the electric potential and the ionic concentration distribution within the channel are adopted to take into account the effect of the electrical double layer (EDL), including the EDL overlap. When the EDL is not overlapped, the velocity profiles for both Newtonian and viscoelastic fluids are plug-like and increase sharply near the charged wall. The velocity profile resembles that of pressure-driven flow when the EDL is …

Eigenstrain As A Mechanical Set-Point Of Cells, Shengmao Lin, Marsha C. Lampi, Cynthia A. Reinhart-King, Gary C.P. Tsui, Jian Wang, Carl A. Nelson, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Cell contraction regulates how cells sense their mechanical environment. We sought to identify the set-point of cell contraction, also referred to as tensional homeostasis. In this work, bovine aortic endothelial cells (BAECs), cultured on substrates with different stiffness, were characterized using traction force microscopy (TFM). Numerical models were developed to provide insights into the mechanics of cell–substrate interactions. Cell contraction was modeled as eigenstrain which could induce isometric cell contraction without external forces. The predicted traction stresses matched well with TFM measurements. Furthermore, our numerical model provided cell stress and displacement maps for inspecting the fundamental regulating mechanism of cell …

Ureteral Tunnel Length Versus Ureteral Orifice Configuration In The Determination Of Ureterovesical Junction Competence: A Computer Simulation Model, Carlos A. Villanueva, J. Tong, Carl A. Nelson, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction The long-held belief that a ureteral re-implant tunnel should be five times the diameter of the ureter, as proposed by Paquin in 1959, ignores the effect of the orifice on the occurrence of reflux. In 1969, Lyon proposed that the shape of the ureteral orifice (UO) is more important than the intravesical tunnel. However, both theories missed quantitative evidence from principles of physics. The goal of the current study was to test Lyon’s theory through numerical models (i.e. to quantify the sensitivity of ureterovesical junction (UVJ) competence to intravesical tunnel length and to the UO).

Materials and methods The …

Improved A-B10C2+XHY/Si P-N Heterojunction Performance After Neutron Irradiation, George Peterson, Qing Su, Yongqiang Wang, Natale J. Ianno, Peter Dowben, Michael Nastasi

Department of Mechanical and Materials Engineering: Faculty Publications

The impact of neutron irradiation, in the energy range of ~0.025 eV, on amorphous semiconducting partially dehydrogenated boron carbide (a-B₁₀C_2+xH_y) on silicon p-n heterojunction diodes was investigated. The heterojunction devices were created by synthesizing a-B₁₀C_2+xH_y via plasma enhanced chemical vapor deposition on n-type silicon. Unlike many electronic devices, the performance of the a-B₁₀C_2+xH_y heterojunction diode improved with neutron irradiation, in spite of the large neutron cross section of ¹⁰B. There is also increased charge carrier lifetime of more than …

Excess Charge-Carrier Induced Instability Of Hybrid Perovskites, Yuze Lin, Bo Chen, Yanjun Fang, Jingjing Zhao, Chunxiong Bao, Zhenhua Yu, Yehao Deng, Peter N. Rudd, Yanfa Yan, Yongbo Yuan, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

Identifying the origin of intrinsic instability for organic–inorganic halide perovskites (OIHPs) is crucial for their application in electronic devices, including solar cells, photodetectors, radiation detectors, and light-emitting diodes, as their efficiencies or sensitivities have already been demonstrated to be competitive with commercial available devices. Here we show that free charges in OIHPs, whether generated by incident light or by current-injection from electrodes, can reduce their stability, while efficient charge extraction effectively stabilizes the perovskite materials. The excess of both holes and electrons reduce the activation energy for ion migration within OIHPs, accelerating the degradation of OIHPs, while the excess holes …

An Integrated Microstructural-Nanomechanical-Chemical Approach To Examine Material-Specific Characteristics Of Cementitious Interphase Regions, Mahdieh Khedmati, Yong-Rak Kim, Joseph A. Turner, Hani Alanazi, Charles Nguyen

Department of Mechanical and Materials Engineering: Faculty Publications

Effective properties and structural performance of cementitious mixtures are substantially governed by the quality of the interphase region because it acts as a bridge transferring forces between aggregates and a binding matrix and is generally susceptible to damage. As alternative binding agents like alkali-activated precursors have obtained substantial attention in recent years, there is a growing need for fundamental knowledge to uncover interphase formation mechanisms. In this paper, two different types of binding materials, i.e., fly ash-based geopolymer and ordinary portland cement, were mixed with limestone aggregate to examine and compare the microstructures and nanomechanical properties of interphase region. To …

An Integrated Microstructural-Nanomechanical-Chemical Approach To Examine Material-Specific Characteristics Of Cementitious Interphase Regions, Mahdieh Khedmati, Yong-Rak Kim, Joesph A. Turner, Hani Alanazi, Charles Nguyen

Department of Mechanical and Materials Engineering: Faculty Publications

Effective properties and structural performance of cementitious mixtures are substantially governed by the quality of the interphase region because it acts as a bridge transferring forces between aggregates and a binding matrix and is generally susceptible to damage. As alternative binding agents like alkali-activated precursors have obtained substantial attention in recent years, there is a growing need for fundamental knowledge to uncover interphase formation mechanisms. In this paper, two different types of binding materials, i.e., fly ash-based geopolymer and ordinary portland cement, were mixed with limestone aggregate to examine and compare the microstructures and nanomechanical properties of interphase region. To …

Molecular Doping Enabled Scalable Blading Of Efficient Hole-Transport-Layer-Free Perovskite Solar Cells, Wu-Qiang Wu, Qi Wang, Yanjun Fang, Yuchuan Shao, Shi Tang, Yehao Deng, Haidong Lu, Ye Liu, Tao Li, Zhibin Yang, Alexei Gruverman, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of other functional layers. By simplifying the device architecture, hole-transport-layer-free PSCs with improved photovoltaic performance are fabricated via a scalable doctor-blading process. Molecular doping of halide perovskite films improved the conductivity of the films and their electronic contact with the conductive substrate, resulting in a reduced series resistance. It facilitates the extraction of photoexcited holes from perovskite directly …

Visible Light Crosslinkable Human Hair Keratin Hydrogels, Kan Yue, Yanhui Liu, Batzaya Byambaa, Vaishali Singh, Wanjun Liu, Xiuyu Li, Yunxia Sun, Yu Shrike Zhang, Ali Tamayol, Peihua Zhang, Kee Woei Ng, Nasim Annabi, Ali Khademhosseini

Department of Mechanical and Materials Engineering: Faculty Publications

Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential to engineer autologous tissue constructs. However, the fabrication of keratin-based scaffolds typically relies on limited crosslinking mechanisms, such as via physical interactions or disulfide bond formation, which are time-consuming and result in relatively poor mechanical strength and stability. Here, we report the preparation of photocrosslinkable keratin-polyethylene glycol (PEG) hydrogels via the thiol-norbornene “click” reaction, which can be formed within one minute upon irradiation of visible light. The resulting keratin-PEG hydrogels showed …

Complementary Microscopy Techniques Applied For Characterizing The Localized Nanoscale Structure Of Poly (Vinylidene Fluoride), Wen Qian, Shuo Sun, Charles Nguyen, Wenlong Li, Stephen Ducharme, Joesph A. Turner

Department of Mechanical and Materials Engineering: Faculty Publications

Poly (vinylidenefluoride) (PVDF), a well-recognized electroactive polymer, has been studied extensively over many decades. Recently, there has been increasing interest in tuning the electrical properties of PVDF from ferroelectric to piezoelectric and to pyroelectric, which can be attained via controlling the microscale structure down to the nanoscale structure [1-2]. To optimize the preparation conditions of PVDF and its copolymers, as well as to improve the performance for many applications, comprehensive analytical techniques are of great importance. In this paper, we demonstrate complementary nanoscale characterization and measurement techniques, by conducting a systematic and coordinated study involving scanning electron microscopy (SEM), high …

Flow Patterns Through Vascular Graft Models With And Without Cuffs, Chia Min Leong, Gary B. Nackman, Timothy Wei

Department of Mechanical and Materials Engineering: Faculty Publications

The shape of a bypass graft plays an important role on its efficacy. Here, we investigated flow through two vascular graft designs±with and without cuff at the anastomosis. We conducted Digital Particle Image Velocimetry (DPIV) measurements to obtain the flow field information through these vascular grafts. Two pulsatile flow waveforms corresponding to cardiac cycles during the rest and the excitation states, with 10% and without retrograde flow out the proximal end of the native artery were examined. In the absence of retrograde flow, the straight end-to-side graft showed recirculation and stagnation regions that lasted throughout the full cardiac cycle with …

Dislocations Interaction Induced Structural Instability In Intermetallic Al2cu, Qing Zhou, Jian Wang, Amit Misra, Ping Huang, Fei Wang, Kewei Xu

Department of Mechanical and Materials Engineering: Faculty Publications

Intermetallic precipitates are widely used to tailor mechanical properties of structural alloys but are often destabilized during plastic deformation. Using atomistic simulations, we elucidate structural instability mechanisms of intermetallic precipitates associated with dislocation motion in a model system of Al₂Cu. Interaction of non-coplanar <001> dislocation dipoles during plastic deformation results in anomalous reactions—the creation of vacancies accompanied with climb and collective glide of <001> dislocation associated with the dislocation core change and atomic shuffle—accounting for structural instability in intermetallic Al₂Cu. This process is profound with decreasing separation of non-coplanar dislocations and increasing temperature and is likely to be …

Mechanical Performance Of Plla Stent, Longzhen Wang, Junfei Tong, Pengfei Dong, David L. Wilson, Hiram G. Bezerra, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Stent implantation is widely used to treat blocked lumen. Stents were meshed structure made of polymers and metal alloys, including stainless steel, cobalt chrome and nitinol [1]. Clinical studies had demonstrated that stents helped to scaffold the diseased lesion up to one year when tissue adapted to the stented environment [2]. However, the permanently implanted stents inside artery were associated with complications such as stent fracture, tissue inflammation, in-stent restenosis and thrombosis [3]. Currently, biodegradable stents are attracting more attention due to its potential long-term efficacy in treating blocked lumens. The detailed characterizations of biodegradable stents are essential for the …

Tissue Stresses In Stented Coronary Arteries With Different Geometries: Effect Of The Relation Between Stent Length And Lesion Length, Xiang Shen, Song Ji, Yong-Quan Deng, Hong-Fei Zhu, Jia-Bao Jiang, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

In-stent restenosis after stent deployment remains an obstruction in the long-term benefits of stenting. This study sought to investigate the influence of the relation between stent length and lesion length on the mechanics of the arterial wall with different geometries, including straight and tapered vessels. Results showed that when the length of the stent was longer than the lesion length, the maximum stress in plaque and vessel increased as the length of stent increased. When the length of the stent was shorter than the lesion length, the vessel stress induced by stent inflation was lower; both ends of the stenosis …

Scaffold Structural Microenvironmental Cues To Guide Tissue Regeneration In Bone Tissue Applications, Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold …