Nanoscience and Nanotechnology Commons^™

3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment of PRP …

Time Dependence Of Self-Assembly Process For The Formation Of Inorganic-Organic Hybrid Nanolayers, Alexandre Dhôtel

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

There is increasing interest in self-assembled materials for energy storage, flexible electronics and hydrophobic barriers. Inorganic/organic hybrid thin films and especially organosilane-based coatings already have demonstrated their ability to achieve those goals. However, some fundamental points of their formation process by molecular self-assembly remain unexplained. Although the literature widely reports the effect of temperature on the final nanostructure, until now, no one has taken into account the importance of time during their synthesis.

The main objective of this study was to improve and complete the understanding of mechanisms responsible for the self-organization of organic/inorganic molecules into a highly ordered, layered …