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Optimizing Fermentation Medium To Produce Cyclosporin A Using Response Surface Methodology, Rofiq Sunaryanto
Optimizing Fermentation Medium To Produce Cyclosporin A Using Response Surface Methodology, Rofiq Sunaryanto
Makara Journal of Technology
Response surface methodology (RSM) is a three factorial model which illustrates the relationship between one or more independent variables. RSM can be used to optimize the fermentation medium for the production of Cyclosporin A from the isolate Tolypocladium inflatum. The optimal point of the response surface area is predicted by using a seconddegree polynomial model and applying the statistic model obtained from the central composite design (CCD). The results of optimizing the fermentation medium for Cyclopsorin using the three independent variables of glucose, casein, and KH2PO4 show that all three of the independent variables affect the production of Cyclosporin A. …