Mechanical Engineering Commons^™

Extension Of A Penalty Method For Numerically Solving Constrained Multibody Dynamic Problems, Troy Newhart

Mechanical & Aerospace Engineering Theses & Dissertations

Numerical analysis of constrained static and multibody dynamic systems has become an integral part of engineering analysis with the continued improvements in technology and software availability. Many methods currently exist for numerically solving constrained static and dynamic systems. The applicability of a penalty method for constrained static solutions is observed in many academic texts and papers. The appeal for using a penalty method in statics pertains to its ease of implementation, computational suitability, and accuracy. This thesis extends a static penalty method for use with constrained multibody dynamics to observe if the penalty method’s benefits are similar for a dynamics …

Effect Of The Physical Micro-Environment On Cell Adhesion And Force Exertion, Mohamad Eftekharjoo

Mechanical & Aerospace Engineering Theses & Dissertations

Physical characteristics of the microenvironment, such as geometry and stiffness, influence cell adhesion and contractile forces. Here, we determined how these physical factors influenced cell force exertion and adhesion in two specific contexts that have broad relevance.

Fibroblasts are cells in connective tissues that interact with a fibrous extracellular matrix (ECM) that have a predominantly one-dimensional (1D) (fibrillar) geometry. However, it has been unclear as to how the 1D nature of the fibrillar ECM influences the forces exerted by fibroblasts. Here, we used fibroblast cells adherent on fibronectin lines on polyacrylamide (PAA) gels of stiffness 13 and 45 kPa to …

A Cfd Study Of Steady Fully Developed Laminar Flow Through A 90-Degree Bend Pipe With A Square Cross-Sectional Area, Subodh Sushant Toraskar

Mechanical & Aerospace Engineering Theses & Dissertations

Fluid flow through a closed curved conduit has always been a topic of extensive research, as it has many practical and industrial applications. The flow is generally characterized by a presence of secondary flow, vortical motions and pressure losses for different flow regimes. These observed irregularities may positively or negatively impact the flow. They are beneficial for cases where mixing of fluids is required, usually observed for multiphase flow regimes or detrimental for cases involving particles in the fluid. There are also instances where a particle-laden fluid transported through the curved pipe was directly related to corrosion- erosion related problems. …

Computational Analysis And Design Optimization Of Convective Pcr Devices, Jung Il Shu

Mechanical & Aerospace Engineering Theses & Dissertations

Polymerase Chain Reaction (PCR) is a relatively novel technique to amplify a few copies of DNA to a detectable level. PCR has already become common in biomedical research, criminal forensics, molecular archaeology, and so on. Many have attempted to develop PCR devices in numerous types for the purpose of the lab-on-chip (LOC) or point-of-care (POC). To use PCR devices for POC lab testing, the price must be lower, and the performance should be comparable to the lab devices. For current practices with the existing methods, the price is pushed up higher partially due to too much dependence on numerous developmental …

Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote

Mechanical & Aerospace Engineering Theses & Dissertations

Innovations in computer technology made way for Computational Fluid Dynamics (CFD) into engineering, which supported the development of new designs by reducing the cost and time by lowering the dependency on experimentation. There is a further need to make the process of development more efficient. One such technology is Artificial Intelligence. In this thesis, we explore the application of Artificial Intelligence (AI) in CFD and how it can improve the process of development.

AI is used as a buzz word for the mechanism which can learn by itself and make the decision accordingly. Machine learning (ML) is a subset of …

Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles

Mechanical & Aerospace Engineering Theses & Dissertations

The aim of this thesis is to explore methods to reduce the noise impact of unmanned aerial vehicles operating within acoustically sensitive environments by flight control system augmentation. Two methods are investigated and include: (i) reduction of sound generated by vehicle speed control while flying along a nominal path and (ii) reduction of acoustic exposure by vehicle path control while flying at a nominal speed. Both methods require incorporation of an acoustic model into the flight control system as an additional control objective and an acoustic metric to characterize primary noise sources dependent on vehicle state. An acoustic model was …

Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali

Mechanical & Aerospace Engineering Theses & Dissertations

In epithelial tissues, epithelial cells adhere to each other as well as to the underlying extra-cellular matrix (ECM). E-cadherin-based intercellular junctions play an important role in tissue integrity. These junctions experience cell-generated mechanical forces via apparent adaptor proteins such as beta (β) catenin, alpha (α) catenin and vinculin. Abnormalities in these junctions may result in skin related diseases and cancers. Here, I devised methods to determine the endogenous intercellular force within cell pairs as well as in large epithelial islands. I further ascertained the factors that affect the level of inter-cellular tension.

Experiments with pairs of epithelial cells exogenously expressing …

Off Axis Compressive Response Of Ice-Templated Ceramics, Rahul Kumar Jujjavarapu

Mechanical & Aerospace Engineering Theses & Dissertations

The off-axis compressive behavior of ice-templated ceramic was analyzed using experimental results and micro-mechanical model simulation. Ice-templated ceramics is a versatile processing technique used to manufacture anisotropic ceramic foam by exploiting the anisotropic growth characteristics and lamellar morphology. The ice-templating process results in processing-structure-property relationships determined by the microstructure. The processed alumina samples which were later manufactured by water jet machine from the freeze casting were tested under quasi-static off-axis loading conditions and were used to determine the mechanical properties of the material. Digital image correlation (DIC) was used to measure the strain response of ice-templated ceramic under off-axis loading. …

Design And Manufacture Of An Inertial Cascade Impactor For Industrial Hygiene Purposes, Hector Joel Gortaire

Mechanical & Aerospace Engineering Theses & Dissertations

Inertial cascade impactors are devices commonly used for industrial hygiene and pharmaceutical studies. Their main purpose is to separate particulate matter suspended in aerosols according to their sizes, which can vary from over 10 µm to 0.5 µm. Their versatility and ease of operation make them suitable for on-site sampling; however, designing them requires a careful consideration of the different geometric parameters that characterize them.

In this thesis, a 5-stage inertial cascade impactor was designed, modelled, constructed, and tested. The main design parameter was the volumetric flow rate, 40 l/min, which was provided by a vacuum pump. By continuous iterations, …

Characterization And Optimization Of A Propeller Test Stand, Colin Bruce Leighton Benjamin

Mechanical & Aerospace Engineering Theses & Dissertations

In recent history, there has been a rapid rise in the use of drones, and they are expanding in popularity each year. The widespread use and future capabilities of these unmanned aerial vehicles (UAVs) will call for increased study and classification of propellers to maximize their performance. As a result, it is necessary to have continuity in the development, maximization, and optimization of propeller test stand’s capability to collect accurate and precise measurements. It is of significant advantage to have the capability of accurately characterizing a propeller based on its thrust and torque. In this study, a propeller test stand …

Numerical Simulation Of Viscoelastic Flow In Micro/Nanochannels, Lanju Mei

Mechanical & Aerospace Engineering Theses & Dissertations

Micro/Nanofluidic devices often involve use of biological fluids or polymeric solutions that cannot be simply treated as Newtonian fluids. The numerical simulation for the complex fluids at micro/nanoscale presents a significant computational challenge, and the inclusion of electrokinetic body force further increases the complexity. Specifically, the well-known High Weissenberg Number Problem (HWNP) has become a challenge for the numerical simulation of viscoelastic fluid. This dissertation is aimed to develop a numerical tool to simulate the behavior of viscoelastic fluid in the micro/nanochannel. The most popular log-conformation reformulation to solve the HWNP is presented and implemented in a finite volume scheme. …

Estimation Of Arterial Wall Parameters Via Model-Based Analysis Of Noninvasively Measured Arterial Pulse Signals, Dan Wang

Mechanical & Aerospace Engineering Theses & Dissertations

This dissertation presents a model-based method for estimating arterial wall parameters from noninvasively measured arterial pulse signals via a microfluidic-based tactile sensor. The sensor entails a polydimethylsiloxane (PDMS) microstructure embedded with 5×1 transducer array built on Pyrex/Polyethylene terephthalate (PET) substrate. The arterial pulse causes a time-varying deflection on the top of the PDMS microstructure, which registers as a resistance change by the transducer at the site of the artery.

Owing to the time-harmonic nature of its radial motion, the arterial wall is modeled as a second-order dynamic system. By combining this dynamic model with a hemodynamic model of blood flow, …

Comparison Of Support Methods For Static Aerodynamic Testing And Validation Of A Magnetic Suspension And Balance System, Cameron K. Neill

Mechanical & Aerospace Engineering Theses & Dissertations

Magnetic suspension wind tunnels offer an alternative to traditional physical support methods. They allow for the collection of support interference free data and broader dynamic test capabilities than existing methods. Determination of dynamic aerodynamic characteristics is a crucial portion of the design of new re-entry capsules. A NASA initiative restored the 6-inch Magnetic Suspension and Balance System to support the design of a new MSBS for a supersonic wind tunnel. Before a new MSBS can be constructed, the characteristics of the current MSBS must be examined.

This thesis discusses the calibration and validation of the 6-inch MSBS. After calibration, three …