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Full-Text Articles in Mechanical Engineering
Effect Of Respiration On Cardiac Filling At Rest And During Exercise In Fontan Patients: A Clinical And Computational Modeling Study, Alexander Van De Bruaene, Guido Claessen, Andre La Gerche, Ethan Kung, Alison Marsden, Pieter De Meester, Sarah Devroe, Jan Bogaert, Piet Claus, Hein Heidbuchel, Werner Budts, Marc Gewillig
Effect Of Respiration On Cardiac Filling At Rest And During Exercise In Fontan Patients: A Clinical And Computational Modeling Study, Alexander Van De Bruaene, Guido Claessen, Andre La Gerche, Ethan Kung, Alison Marsden, Pieter De Meester, Sarah Devroe, Jan Bogaert, Piet Claus, Hein Heidbuchel, Werner Budts, Marc Gewillig
Publications
Due to the absence of a sub-pulmonary ventricle, the Fontan circulation is sensitive to respiration-induced changes in intrathoracic pressure. However, the importance of a ‘respiratory pump’ in creating forward flow remains controversial. We aimed at evaluating the effect of respiration on ventricular filling during exercise using clinical data and computational modeling predictions. Ten Fontan patients (6 male, 20 ± 4 years) underwent ungated cardiac magnetic resonance (CMR) imaging at rest and during supine bicycle exercise to evaluate systemic ventricular volumes (end-diastolic volume index (EDVi), end-systolic volume index (ESVi) and stroke volume index (SVi)) during normal respiration and a Valsalva maneuver. …