Mechanical Engineering Commons^™

Sheathless Size-Based Acoustic Particle Separation, Rasim Guldiken, Myeong Chan Jo, Nathan D. Gallant, Utkan Demirci, Jiang Zhe

Mechanical Engineering Faculty Research

Particle separation is of great interest in many biological and biomedical applications. Flow-based methods have been used to sort particles and cells. However, the main challenge with flow based particle separation systems is the need for a sheath flow for successful operation. Existence of the sheath liquid dilutes the analyte, necessitates precise flow control between sample and sheath flow, requires a complicated design to create sheath flow and separation efficiency depends on the sheath liquid composition. In this paper, we present a microfluidic platform for sheathless particle separation using standing surface acoustic waves. In this platform, particles are first lined …