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Production Of Lovastatin And Sulochrin By Aspergillus Terreus Using Solid State Fermentation, Rizna Triana Dewi, Nina Artanti, Hani Mulyani, Puspa Dewi Narrij Lotulung, Minarti Minarti
Production Of Lovastatin And Sulochrin By Aspergillus Terreus Using Solid State Fermentation, Rizna Triana Dewi, Nina Artanti, Hani Mulyani, Puspa Dewi Narrij Lotulung, Minarti Minarti
Makara Journal of Technology
Lovastatin is an anti-cholesterol agent that was produced by Aspergillus terreus using solid state fermentation (SSF). During this fermentation process, sulochrin is also produced as an unwanted co-metabolite. However, our previous result showed that sulochrin had potential as antidiabetes because it is an inhibitor agent of α-glucosidase. In this paper, we reported our observation on lovastatin and sulochrin production pattern in relation with inhibitor α-glucosidase activity during eleven days fermentation of A. terreus koji (SSF) ethyl acetate extract. Koji obtained from solid state fermentation with rice as the substrate and incubated at room temperature, sample is taken daily for eleven …