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Full-Text Articles in Mechanical Engineering
Articular Cartilage Tensile Integrity: Modulation By Matrix Depletion Is Maturation-Dependent, Anna Asanbaeva, Johnny Tam, Barbara L. Schumacher, Stephen M. Klisch, Koichi Masuda, Robert L. Sah
Articular Cartilage Tensile Integrity: Modulation By Matrix Depletion Is Maturation-Dependent, Anna Asanbaeva, Johnny Tam, Barbara L. Schumacher, Stephen M. Klisch, Koichi Masuda, Robert L. Sah
Mechanical Engineering
Articular cartilage function depends on the molecular composition and structure of its extracellular matrix (ECM). The collagen network (CN) provides cartilage with tensile integrity, but must also remodel during growth. Such remodeling may depend on matrix molecules interacting with the CN to modulate the tensile behavior of cartilage. The objective of this study was to determine the effects of increasingly selective matrix depletion on tensile properties of immature and mature articular cartilage, and thereby establish a framework for identifying molecules involved in CN remodeling. Depletion of immature cartilage with guanidine, chondroitinase ABC, chondroitinase AC, and Streptomyces hyaluronidase markedly increased tensile …
A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols, Stephen M. Klisch, Anna Asanbaeva, Sevan R. Oungoulian, Koichi Masuda, Eugene J.-Ma. Thonar, Andrew Davol, Robert L. Sah
A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols, Stephen M. Klisch, Anna Asanbaeva, Sevan R. Oungoulian, Koichi Masuda, Eugene J.-Ma. Thonar, Andrew Davol, Robert L. Sah
Mechanical Engineering
A cartilage growth mixture (CGM) model is proposed to address limitations of a model used in a previous study. New stress constitutive equations for the solid matrix are derived and collagen (COL) remodeling is incorporated into the CGM model by allowing the intrinsic COL material constants to evolve during growth. An analytical validation protocol based on experimental data from a recent in vitro growth study is developed. Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13 days in 20% fetal borine serum …