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Articles 1 - 6 of 6
Full-Text Articles in Mechanical Engineering
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Graduate Research Theses & Dissertations
Isolation of circulating tumor cells (CTCs) from patient derived blood samples for cancerdiagnostics and monitoring is challenging due to the extremely low CTC concentration. This thesis work evaluates the performance of passive microfluidics devices with different designs based on computational modeling. A new cell separation method is proposed based on velocity differentiation of varying cell sizes. All numerical studies were conducted in 2D based on a fluid structure interaction code where the fluid flow was solved based on the lattice Boltzmann method (LBM) implemented in Palabos, and the cell dynamics were simulated based on the molecular dynamics package LAMMPS, with …
Blood Flow Simulation In A Microvascular Network, Kacper Ostalowski
Blood Flow Simulation In A Microvascular Network, Kacper Ostalowski
Graduate Research Theses & Dissertations
Cardiovascular disease such as heart attack or stroke has been the leading cause of death in the US for over 100 years. Understanding the blood cell transport physics in a vascular network is important in both fundamental research and clinical practices. In this study, 3Dnumerical simulations on blood flow in a complex retina vascular network were performed considering deformable red blood cells (RBCs), white blood cells (WBCs), and obstructed vessels. The blood was modeled as a mixture of RBCs and WBCs suspended in fluid. The fluid was solved using the lattice Boltzmann method (LBM), and blood cells were modeled by …
Thermal / Structural Analysis Of The Hb 650 Thermal Shield, Gerald J. Smith
Thermal / Structural Analysis Of The Hb 650 Thermal Shield, Gerald J. Smith
Graduate Research Theses & Dissertations
Fermilab’s PIP-II project’s superconducting linear accelerator (Linac) will drive the next generation of particle accelerators through a revolution in beam intensity. Key to beam intensification are the high efficiencies of niobium-tin superconducting radiofrequency (SRF) cavities operating at cryogenic temperatures near 5 Kelvin. A multifaceted approach is employed to achieve and maintain the extreme temperature. Vacuum provides the first barrier to thermal convection. Physical thermal intercept zones further isolate the exterior shell vacuum vessel at 300 Kelvin from the supercooled beamline. The first thermal intercept lies just inside the exterior vacuum vessel forming the 40 Kelvin zone. This 40K thermal shield …
Effect Of Perturbations On The Dominant Flow Structures In A Rectangular Lid-Driven Cavity With Particle Suspensions, Siva Bolisetty
Effect Of Perturbations On The Dominant Flow Structures In A Rectangular Lid-Driven Cavity With Particle Suspensions, Siva Bolisetty
Graduate Research Theses & Dissertations
The lid-driven cavity is a canonical problem in the field of analytical and computational fluid dynamics. This work is focused on a 2-D rectangular cavity with a length twice the size of its width and consists of an incompressible fluid with a moving upper wall/lid while the rest of the wall boundaries are subjected to fixed, no-slip, zero-velocity boundary conditions. The objective is to investigate the effect of perturbations resulting from particle drag and particle collisions on dominant flow structures of the fluid within this cavity. The dominant flow structures in a rectangular lid-driven cavity constitute a primary vortex, a …
Steady Flows In Annular Wedge Lid-Driven Cavities, Anandan Ganapathy
Steady Flows In Annular Wedge Lid-Driven Cavities, Anandan Ganapathy
Graduate Research Theses & Dissertations
The lid-driven cavity is a well-known canonical problem in the field of analytical and computational fluid dynamics. It is comprised of a square domain of an incompressible fluid with its upper lid has a specified velocity and the remaining wall boundaries are subjected to fixed, no-slip, zero-velocity constraints. There are numerous examples found in the literature that address the well-known, stable behavior of this system, which includes a primary recirculating vortex, secondary corner vortices, and a velocity profile through the center midpoint y-axis that is shown to be dependent on the Reynolds number. In this investigation, the shape of the …
A Computational Fluid Dynamics Analysis Of The Aerodynamic Performance Of Wind Turbine, Ashkan Ostovari
A Computational Fluid Dynamics Analysis Of The Aerodynamic Performance Of Wind Turbine, Ashkan Ostovari
Graduate Research Theses & Dissertations
Renewable energy resources are likely to be a future energy solution. Among them, the wind has gained a lot of interest. Despite the theoretical limitation in wind energy harnessing efficiency, it is, still, one of the most promising renewable resources with utilizing turbines to extract this energy. Wind turbines, based on their axis of rotation are categorized into vertical axis wind turbine (VAWT) and horizontal axis wind turbine (HAWT), which HAWT’s have shown relatively higher efficiency than VAWT’s. The aim of this thesis is first to develop a scaled-down model of a wind turbine in Computational Fluid Dynamics (CFD) environment …