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Full-Text Articles in Mechanical Engineering
Temporally And Spatially Resolved Quantification Of Hemodynamic Forces And Endothelial Mechanics, Lori M. Lambert
Temporally And Spatially Resolved Quantification Of Hemodynamic Forces And Endothelial Mechanics, Lori M. Lambert
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
The endothelium is a thin layer of endothelial cells that line the interior surface of an artery. Due to their direct contact with blood flow, endothelial cells experience varying hemodynamic forces and respond to these forces by altering their morphology. When plaque and other substances accumulate in the walls of arteries, i.e., atherosclerosis, endothelial cells have abnormal responses to blood flow. Studying atherosclerosis progression is, therefore, a two-fold investigation into 1) the hemodynamic forces that cause endothelial responses, and 2) the biological and mechanical responses of endothelial cells. The ultimate goal of this study was to develop an experimental …
Influence Of Shear Stress Magnitude And Direction On Atherosclerotic Plaque Composition, Ryan M. Pedrigi, Vikram V. Mehta, Sandra M. Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L. Tremoleda, Leila Towhidi, Ranil De Silva, Enrico Petretto, Rob Krams
Influence Of Shear Stress Magnitude And Direction On Atherosclerotic Plaque Composition, Ryan M. Pedrigi, Vikram V. Mehta, Sandra M. Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L. Tremoleda, Leila Towhidi, Ranil De Silva, Enrico Petretto, Rob Krams
Department of Mechanical and Materials Engineering: Faculty Publications
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable features upstream and downstream of the cuff, respectively. Herein, we sought to test the hypothesis that changes in flow magnitude promote formation of the upstream (vulnerable) plaque, whereas altered flow direction is important for development of the downstream (stable) plaque. We instrumented ApoE−/− mice (n=7) with a cuff around the left carotid artery and imaged them with micro-CT (39.6 μm resolution) eight to nine weeks …