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Full-Text Articles in Mechanical Engineering
A Microfluidic Multichannel Resistive Pulse Sensor Using Frequency Division Multiplexing For High Throughput Counting Of Micro Particles, Ashish Jagtiani, Joan Carletta, Jiang Zhe
A Microfluidic Multichannel Resistive Pulse Sensor Using Frequency Division Multiplexing For High Throughput Counting Of Micro Particles, Ashish Jagtiani, Joan Carletta, Jiang Zhe
Dr. Jiang Zhe
In this work we demonstrate an on-chip multiplexed multichannel resistive pulse sensor (Coulter counter) for high throughput counting of microscale particles. The design, fabrication and testing of this device are presented. The high throughput counting is a result of using multiple parallel microfluidic channels to analyze the sample. Detection is achieved by using frequency division multiplexing; each microchannel is modulated with its own known and unique frequency, a combined measurement is made across a single pair of electrodes, and the measured signal is demodulated to determine the signal across each individual channel. Testing results using 30 µm polystyrene particles demonstrate …
Effects Of Particle's Off-Axis Position, Shape, Orientation And Entry Position On Resistance Changes Of Micro Coulter Counting Devices, Zhenpeng Qin, Jiang Zhe, Guo-Xiang Wang
Effects Of Particle's Off-Axis Position, Shape, Orientation And Entry Position On Resistance Changes Of Micro Coulter Counting Devices, Zhenpeng Qin, Jiang Zhe, Guo-Xiang Wang
Dr. Jiang Zhe
With the recent advance in micro/nano-fabrication technology, micro Coulter counters have been widely used in detecting and characterizing micro- and nanoscale objects. In this paper, the electrical resistance change during translocation of a non-conducting particle through a channel is studied numerically. The numerical results are validated by proven analytical results available in the literature. The effects of particle's off-axis position, shape and orientation, and entry position are studied for particles with a large dynamic range. From the numerical results, a new fitted correlation is proposed that can accurately predict the resistance change caused by off-axis spherical particles regardless of their …