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Full-Text Articles in Mechanical Engineering
Manufacturing Microfluidic Flow Focusing Devices For Stimuli Responsive Alginate Microsphere Generation And Cell Encapsulation, Michael A. Karasinski
Manufacturing Microfluidic Flow Focusing Devices For Stimuli Responsive Alginate Microsphere Generation And Cell Encapsulation, Michael A. Karasinski
Graduate College Dissertations and Theses
In this paper a novel stimuli responsive hydrogel material, methacrylated sodium alginate beta-cyclodextrin (Alg-MA-β-CD), was used in combination with a microfluidic device to create microspheres. Currently there is no reliable method for fabricating homogeneous stimuli-responsive microspheres, in-house microfluidic devices are not reliable in manufacture quality or long-term use. Alginate hydrogels have many attractive characteristics for bioengineering applications and are commonly used to mimic the features and properties of the extracellular matrix (ECM). Human mesenchymal stem cells (hMSCs) are of top interest to tissue engineers. hMSCs are widely available and can be harvested and cultured directly out of human bone marrow. …
Burst Pressure Properties And Ex Vivo Analysis Of Alginate-Based Hydrogels For Tissue Sealant Applications, Patrick Nelson Charron
Burst Pressure Properties And Ex Vivo Analysis Of Alginate-Based Hydrogels For Tissue Sealant Applications, Patrick Nelson Charron
Graduate College Dissertations and Theses
Lung diseases, cancers, and trauma can result in injury to the connective tissue lining the lung, i.e., the pleura. Pleural injuries lead to pneumothoraxes or pleural effusions, i.e., air or fluid leaking out of the lung respectively, and potential lung collapse - an immediately life threatening condition. While several bioengineered soft tissue sealants exist on the market, there is only one sealant FDA-approved for use in pulmonary surgery. In addition, very limited techniques are presented in the literature for characterizing the burst properties of hydrogel tissue sealants. For my thesis, I proposed to develop a protocol for characterizing the burst …