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Biomechanical Analysis Of Open-Skull High-Rate Traumatic Brain Injury Using Finite Element Mouse Brain Model, Lihong Lu

Electronic Thesis and Dissertation Repository

To better understand traumatic brain injury (TBI), it is necessary to correlate with injuries, which are observed from in vivo laboratory experiments, to brain mechanical responses, which can so far be best predicted by finite element (FE) models. Firstly, a previously validated FE model was improved to investigate the effect of repeated impacts and lateral movements on brain responses to ensure the accuracy and reproducibility of controlled cortical impact (CCI) across different labs. Then, a new FE mouse brain model with the detailed three-dimensional (3D), non-linear vasculature was developed to study how the vasculature affected brain response in CCI and …