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Full-Text Articles in Mechanical Engineering
Fabrication And In Vivo Thrombogenecity Testing Of Nitric Oxide Generating Artificial Lungs, Kagya Amoako, Patrick Montoya, Terry C. Major, Ahmed B. Suhaib, Hitesh Handa, David O. Brant, Mark E. Meyerhoff, Robert H. Bartlett, Keith E. Cook
Fabrication And In Vivo Thrombogenecity Testing Of Nitric Oxide Generating Artificial Lungs, Kagya Amoako, Patrick Montoya, Terry C. Major, Ahmed B. Suhaib, Hitesh Handa, David O. Brant, Mark E. Meyerhoff, Robert H. Bartlett, Keith E. Cook
Mechanical and Industrial Engineering Faculty Publications
Hollow fiber artificial lungs are increasingly being used for long-term applications. However, clot formation limits their use to 1–2 weeks. This study investigated the effect of nitric oxide generating (NOgen) hollow fibers on artificial lung thrombogenicity. Silicone hollow fibers were fabricated to incorporate 50 nm copper particles as a catalyst for NO generation from the blood. Fibers with and without (control) these particles were incorporated into artificial lungs with a 0.1 m2 surface area and inserted in circuits coated tip-to-tip with the NOgen material. Circuits (N = 5/each) were attached to rabbits in a pumpless, arterio-venous configuration and run for …
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Mechanical and Industrial Engineering Faculty Publications
Coagulation upon blood-contacting biomaterials remains a problem for short and long-term clinical applications. This study examined the ability of copper(II)-doped silicone surfaces to generate nitric oxide (NO) and locally inhibit coagulation. Silicone was doped with 3-micron copper (Cu(0)) particles yielding 3 to 10 weight percent (wt%) Cu in 70-μm thick Cu/Silicone polymeric matrix composites (Cu/Si PMCs). At 3, 5, 8 and 10 wt% Cu doping, the surface expression of Cu was 12.1 ± 2.8%, 19.7 ± 5.4%, 29.0 ± 3.8%, and 33.8 ± 6.5% respectively. After oxidizing Cu(0) to Cu(II) by spontaneous corrosion, NO flux, JNO (mol*cm−2*min−1), as measured by …