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Articles 1 - 6 of 6
Full-Text Articles in Mechanical Engineering
Bioresorbable Composite Stents For Enhanced Response Of Vascular Smooth Muscle Cells, Hozhabr Mozafari
Bioresorbable Composite Stents For Enhanced Response Of Vascular Smooth Muscle Cells, Hozhabr Mozafari
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Formation of arterial plaque and stenosis is one of the main cardiovascular disease risk factors. Stenting is a popular approach to increase the inner diameter of the artery and provide an acceptable lumen gain. This is achieved by applying internal pressure to the arterial wall. Despite the desirable outcomes of this procedure, there are complexities and challenges that are being discussed among scholars in this area. Restenosis is one of these complications, in which smooth muscles cell start proliferation and remodeling in response of induced mechanical stresses. Another important issue is the placement of the stent and possible migration due …
Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu
Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
A computational framework was implemented and validated to better understand the hypertensive artery remodeling in both geometric dimensions and material properties. Integrating the stress-modulated remodeling equations into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both arterial thickening and stiffening effects were captured and visualized. An adaptive material remodeling strategy combined with the element birth and death techniques for the geometrical growth were implemented. The numerically predicted remodeling results in terms of the wall thickness, inner diameter, and the ratio of elastin to collagen content of the artery were compared with and fine-tuned by …
Passive Biaxial Mechanical Properties And In Vivo Axial Pre-Stretch Of The Diseased Human Femoropopliteal And Tibial Arteries, Alexey Kamenskiy, Iraklis I. Pipinos, Yuris A. Dzenis, Clay Lomneth, Syed A. Jaffar Kazmi, Nicholas Y. Phillips, Jason N. Mactaggart
Passive Biaxial Mechanical Properties And In Vivo Axial Pre-Stretch Of The Diseased Human Femoropopliteal And Tibial Arteries, Alexey Kamenskiy, Iraklis I. Pipinos, Yuris A. Dzenis, Clay Lomneth, Syed A. Jaffar Kazmi, Nicholas Y. Phillips, Jason N. Mactaggart
Department of Mechanical and Materials Engineering: Faculty Publications
Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms, or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n=10), popliteal (PA, n=8), and tibial arteries (TA, n=3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All …
Experimental Assessment Of The Impact Of Asymptomatic Gas Emboli On The Vessel Wall, Linxia Gu, Eric L. Cutler
Experimental Assessment Of The Impact Of Asymptomatic Gas Emboli On The Vessel Wall, Linxia Gu, Eric L. Cutler
Department of Mechanical and Materials Engineering: Faculty Publications
Quantitative evaluation of shear stress in the vessel wall due to the presence of asymptomatic gas emboli is lacking. The goal of this work was to assess the impact of chronic asymptomatic gas emboli on the risk of atherosclerosis through a custom-built cardiovascular flow simulator. Gas bubbles were created by forced air from a syringe pump. The influences of embolism injection rate, pulse rate, and time-averaged flow rate on the wall mean shear stress were investigated at resting and elevated heart rate conditions. The recorded pressure and volumetric flow rate from 24 experimental settings with four repetitions each were used …
Gas Embolic Factors In Cardiovascular Health, Eric L. Cutler
Gas Embolic Factors In Cardiovascular Health, Eric L. Cutler
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Gas emboli are a clinical issue often encountered in the space exploration, marine construction, and medical fields. Individuals involved with these disciplines will often have asympomatic gas emboli circulating throughout their bodies on a regular basis. A study into the impact of chronic asymptomatic gas emboli on the risk of atherosclerosis in humans is thus presented. This research utilized a custom built cardiovascular flow simulator and accompanying data acquisition system to experimentally determine the influence of gas emboli under varied circumstances on the mean wall shear stress of a tube in-vitro. A directly inverse relationship between gas embolus presence in …
The Relation Between The Arterial Stress And Restenosis Rate After Coronary Stenting, Linxia Gu, Shijia Zhao, Aswini K. Muttyam, James M. Hammel
The Relation Between The Arterial Stress And Restenosis Rate After Coronary Stenting, Linxia Gu, Shijia Zhao, Aswini K. Muttyam, James M. Hammel
Department of Mechanical and Materials Engineering: Faculty Publications
Two commercially available stents (the Palmaz–Schatz (PS) and S670 stents) with reported high and low restenosis rates, respectively, have been investigated in this paper. Finite element models simulating the stent, plaque, and artery interactions in 3 mm stenosed right coronary arteries were developed. These models were used to determine the stress field in artery walls after stent implantation. The material properties of porcine arteries were measured and implemented in the numerical models. The stress concentration induced in the artery by the PS stent was found to be more than double that of the S670 stent. It demonstrated a good correlation …