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Full-Text Articles in Mechanical Engineering
Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu
Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu
Doctoral Dissertations
Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical stimuli in the skeleton are an important microenvironmental parameter that modulates tumor formation, osteolysis, and tumor cell-bone cell signaling, but which mechanical signals are the most beneficial and the corresponding molecular mechanisms are unknown. This work focused on bone matrix deformation and interstitial fluid flow based on their well-known roles in bone remodeling and in primary breast cancer. The goal of our research was to establish a platform that could define the relationship between …
Streamwise Flow-Induced Oscillations Of Bluff Bodies - The Influence Of Symmetry Breaking, Tyler Gurian
Streamwise Flow-Induced Oscillations Of Bluff Bodies - The Influence Of Symmetry Breaking, Tyler Gurian
Masters Theses
The influence of symmetry breaking on the flow induced oscillations of bluff bodies in the steamwise direction is studied. First, a series of experiments is conducted on a one-degree-of-freedom circular cylinder allowed to exhibit pure translational motion in the streamwise direction over a range of reduced velocities, 1.4 < U* < 4.4, corresponding to a Reynolds number range of 970 < Re < 3370. Two distinct regions of displacements were observed in reduced velocity ranges of 1.6 < U* < 2.5 and 2.75 < U* < 3.85. Measured force coefficients in the drag and lift direction were examined, along with the wake visualization, through the range of reduced velocities, to infer the resulting wake modes. A new Alternating Symmetric (AS) mode was found. This transition from symmetric to AS shedding occurred near the end of the first region of response. Similar tests were run with a square prism in the parameter space of 2.4 < U* < 5.8 and 757 < Re < 1900 over angles of incidence of 0° ≤ α ≤ 45°. A distinct region of lock-in is observed for α = 0°, 2.5°, 5°, 7.5° over 3.2 < U* < 5.4 for α = 0°, and decreasing with increasing α. The wake structures were found to be roughly symmetric for α = 0°, but transitioned towards asymmetry …