Mechanical Engineering Commons^™

Mitochondrial Dynamics And Respiration Within Cells With Increased Open Pore Cytoskeletal Meshes, David H. Jang, Sarah C. Seeger, Martha E. Grady, Frances S. Shofer, David M. Eckmann

Mechanical Engineering Faculty Publications

The cytoskeletal architecture directly affects the morphology, motility, and tensional homeostasis of the cell. In addition, the cytoskeleton is important for mitosis, intracellular traffic, organelle motility, and even cellular respiration. The organelle responsible for a majority of the energy conversion for the cell, the mitochondrion, has a dependence on the cytoskeleton for mobility and function. In previous studies, we established that cytoskeletal inhibitors altered the movement of the mitochondria, their morphology, and their respiration in human dermal fibroblasts. Here, we use this protocol to investigate applicability of power law diffusion to describe mitochondrial locomotion, assessment of rates of fission and …

Transient Analysis Of Fracture Initiation In A Coupled Thermoelastic Solid, Louis Milton Brock

Mechanical Engineering Faculty Publications

An isotropic, thermoelastic solid is initially at rest at uniform (absolute) temperature, and contains a semi-infinite, plane crack. Application of in-plane and normal point forces to each face of the crack causes transient 3D growth. The related problem of discontinuities in temperature and displacement that exist on regions that exhibit dynamic similarity is first considered. Asymptotic expressions, whose inverses are valid near the crack edges for short times, are obtained in integral transform space. These lead to equations of the Wiener–Hopf type for the fracture problem. Analytical solutions are obtained and, upon inversion, subjected to a dynamic energy release rate …

Universality Of Local Dissipation Scales In Turbulent Boundary Layer Flows With And Without Free-Stream Turbulence, Sabah F. H. Alhamdi, Sean C. C. Bailey

Mechanical Engineering Faculty Publications

Measurements of the small-scale dissipation statistics of turbulent boundary layer flows with and without free-stream turbulence are reported for Re_τ ≈ 1000 (Re_θ ≈ 2000). The scaling of the dissipation scale distribution is examined in these two boundary conditions. Results demonstrated that the local large-scale Reynolds number based on the measured longitudinal integral length scale fails to properly normalize the dissipation scale distribution near the wall in these two free-stream conditions due to the imperfect characterization of the upper bound of the inertial cascade by the integral length scale. A surrogate found from turbulent kinetic energy and …

Computational Sensitivity Investigation Of Hydrogel Injection Characteristics For Myocardial Support, Hua Wang, Christopher B. Rodell, Madonna E. Lee, Neville N. Dusaj, Joseph H. Gorman Iii, Jason A. Burdick, Robert C. Gorman, Jonathan F. Wenk

Mechanical Engineering Faculty Publications

Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have demonstrated that hydrogel injections can mitigate the adverse remodeling due to MI. More importantly, the material properties of these injections influence the efficacy of the therapy. The goal of the current study is to explore the interrelated effects of injection stiffness and injection volume on diastolic ventricular wall stress and thickness. To achieve this, finite element models were constructed with different hydrogel injection volumes (150 µL and 300 µL), where the modulus was assessed over a range of 0.1 kPa …

Rapid Characterization Of Local Shape Memory Properties Through Indentation, Peizhen Li, Haluk E. Karaca, Yang-Tse Cheng

Mechanical Engineering Faculty Publications

Shape memory alloys (SMAs) have the ability to show large recoverable shape changes upon temperature, stress or magnetic field cycling. Their shape memory, material and magnetic properties (e.g. transformation temperatures, strain, saturation magnetization and strength) determine their prospects for applications from small-scale microelectromechanical systems to large scale aerospace and biomedical systems. It should be noted that properties of SMAs are highly temperature dependent. Generally, the conventional mechanical characterization methods (e.g, tension, compression, and torsion) are used on bulk samples of SMAs to determine those properties. In this article, it will be shown that indentation technique can be used as an …

Additional Data Via Autonomous Systems To Supplement Traditional Sparse Sources For Weather Forecasting And Atmospheric Science, Suzanne Weaver Smith

Commonwealth Computational Summit

No abstract provided.

The Effect Of Inlet Pulsations On Primary Atomization Of Liquid Jets, Kyle Windland, Prashant Khare

Commonwealth Computational Summit

Objectives

• Elucidate the physics underlying the primary atomization of liquid jets.
• Investigate the effect of inlet pulsations on the atomization process.
• Identify the reliability of numerical predictions using uncertainty quantification techniques (UQ) and sensitivity analyses.

High-Fidelity Simulations Of Water Jet In Air Crossflow, Austin Johnston, Prashant Khare

Commonwealth Computational Summit

Objectives

• Investigate detailed physics underlying liquid jets in crossflow configurations applicable to various applications such as, gas-turbine, scramjet, and afterburner fuel injection.
• Develop models to predict the statistical behaviors of resulting droplets.

Note On The Rate And Energy Efficiency Limits For Additive Manufacturing, Timothy Gutowski, Sheng Jiang, Daniel Cooper, Gero Corman, Michael Hausmann, Jan-Anders Manson, Timo Schudeleit, Konrad Wegener, Matias Sabelle, Jorge Ramos-Grez, Dusan P. Sekulic

Mechanical Engineering Faculty Publications

We review the process rates and energy intensities of various additive processing technologies and focus on recent progress in improving these metrics for laser powder bed fusion processing of metals, and filament and pellet extrusion processing of polymers and composites. Over the last decade, observed progress in raw build rates has been quite substantial, with laser metal processes improving by about 1 order of magnitude, and polymer extrusion processes by more than 2 orders of magnitude. We develop simple heat transfer models that explain these improvements, point to other possible strategies for improvement, and highlight rate limits. We observe a …

Development Of An Unmanned Aerial Vehicle For The Measurement Of Turbulence In The Atmospheric Boundary Layer, Brandon M. Witte, Robert F. Singler, Sean C. C. Bailey

Mechanical Engineering Faculty Publications

This paper describes the components and usage of an unmanned aerial vehicle developed for measuring turbulence in the atmospheric boundary layer. A method of computing the time-dependent wind speed from a moving velocity sensor data is provided. The physical system built to implement this method using a five-hole probe velocity sensor is described along with the approach used to combine data from the different on-board sensors to allow for extraction of the wind speed as a function of time and position. The approach is demonstrated using data from three flights of two unmanned aerial vehicles (UAVs) measuring the lower atmospheric …

Orientation Dependent Compression Behavior Of Co35Ni35Al30 Single Crystals, Peizhen Li, Haluk E. Karaca, Yury I. Chumlyakov

Mechanical Engineering Faculty Publications

The shape memory effect (SME) and superelasticity (SE) behavior of homogenized Co₃₅Ni₃₅Al₃₀ single crystals were systematically characterized along the [100], [110] and [111] orientations under compression. The shape memory behavior of CoNiAl was found to be highly orientation and stress/temperature dependent. Maximum compressive recoverable strains were 3.98 % in [110], 3 % in [100] and 0.30 % in [111] orientations, respectively. The Co₃₅Ni₃₅Al₃₀ demonstrated a very high superelastic temperature window of more than 350 °C along the [100] and [110] orientations. Moreover, two-way shape memory effect with very low thermal …

High Resolution Imaging Of The Mitral Valve In The Natural State With 7 Tesla Mri, Sam E. Stephens, Serguei Liachenko, Neil B. Ingels, Jonathan F. Wenk, Morten O. Jensen

Mechanical Engineering Faculty Publications

Imaging techniques of the mitral valve have improved tremendously during the last decade, but challenges persist. The delicate changes in annulus shape and papillary muscle position throughout the cardiac cycle have significant impact on the stress distribution in the leaflets and chords, thus preservation of anatomically accurate positioning is critical. The aim of this study was to develop an in vitro method and apparatus for obtaining high-resolution 3D MRI images of porcine mitral valves in both the diastolic and systolic configurations with physiologically appropriate annular shape, papillary muscle positions and orientations, specific to the heart from which the valve was …

Pulsed Laser Beam Welding Of Pd43Cu27Ni10P20 Bulk Metallic Glass, Ling Shao, Amit Datye, Jiankang Huang, Jittisa Ketkaew, Sung Woo Sohn, Shaofan Zhao, Sujun Wu, Yuming Zhang, Udo D. Schwarz, Jan Schroers

Electrical and Computer Engineering Faculty Publications

We used pulsed laser beam welding method to join Pd₄₃Cu₂₇Ni₁₀P₂₀ (at.%) bulk metallic glass and characterized the properties of the joint. Fusion zone and heat-affected zone in the weld joint can be maintained completely amorphous as confirmed by X-ray diffraction and differential scanning calorimetry. No visible defects were observed in the weld joint. Nanoindentation and bend tests were carried out to determine the mechanical properties of the weld joint. Fusion zone and heat-affected zone exhibit very similar elastic moduli and hardness when compared to the base material, and the weld joint shows high …

Maximizing Operating Room Performance Using Portfolio Selection, Vivek Reddy Gunna, Amin Abedini, Wei Li

Mechanical Engineering Faculty Publications

The operating room (OR) is responsible for most hospital admissions and is one of the most cost and work intensive areas in the hospital. From recent trends, we observe an ironic parallel increase among expenditure and waiting time. Therefore, improving OR scheduling has become obligatory, particularly in terms of patient flow and benefit. Most of the hospitals rely on average patient arrivals and processing times in OR planning. But in practice, variations in arrivals and processing times causes high instability in OR performance. Our model of optimization provides OR schedules maximizing patient flow and benefit at a fixed level of …

An Optimization Model For Operating Room Scheduling To Reduce Blocking Across The Perioperative Process, Amin Abedini, Wei Li, Honghan Ye

Mechanical Engineering Faculty Publications

Operating room (OR) scheduling is important. Because of increasing demand for surgical services, hospitals must provide high quality care more efficiently with limited resources. When constructing the OR schedule, it is necessary to consider the availability of downstream resources, such as intensive care unit (ICU) and post anaesthesia care unit (PACU). The unavailability of downstream resources causes blockings between every two consecutive stages. In this paper we address the master surgical schedule (MSS) problem in order to minimize blockings between two consecutive stages. First, we present a blocking minimization (BM) model for the MSS by using integer programming, based on …

Techno-Economic Analysis Of A Secondary Air Stripper Process, J. R. Heberle, Heather Nikolic, Jesse Thompson, Kunlei Liu, Lora L. Pinkerton, David Brubaker, James C. Simpson, Song Wu, Abhoyjit S. Bhown

Center for Applied Energy Research Faculty and Staff Publications

We present results of an initial techno-economic assessment on a post-combustion CO₂ capture process developed by the Center for Applied Energy Research (CAER) at the University of Kentucky using Mitsubishi Hitachi Power Systems’ H3-1 aqueous amine solvent. The analysis is based on data collected at a 0.7 MWe pilot unit combined with laboratory data and process simulations. The process adds a secondary air stripper to a conventional solvent process, which increases the cyclic loading of the solvent in two ways. First, air strips additional CO₂ from the solvent downstream of the conventional steam-heated thermal stripper. This extra stripping …

Thermal Degradation Pathways Of Aqueous Diamine Co2 Capture Solvents, Jesse Thompson, Henry Richburg, Kunlei Liu

Center for Applied Energy Research Faculty and Staff Publications

Diamines have shown promise as CO₂ capture solvents, yet very little is known about their pathway for thermal degradation. In this study, diamine thermal degradation was quantitatively monitored in lab-scale experiments on four aqueous diamine solvents; ethylenediamine (EDA) 1,2-propanediamine (1,2-DAP), 1,3-diaminopropane (1,3-DAP) and N-methyl-1,2-ethanediamine (NMEDA), to gain a more comprehensive understanding of their degradation pathway(s). The major degradation products were identified by high resolution time-of-flight mass spectrometry (TOF-MS). Degradation pathways were proposed showing that the primary thermal degradation route for this class of amine are through carbamate formation followed by intermolecular cyclization to form an imidazolidinone or nucleophilic attack …

Solubility And Thermodynamic Modeling Of Carcinogenic Nitrosamines In Aqueous Amine Solvents For Co2 Capture, Jesse Thompson, Naser Matin, Kunlei Liu

Center for Applied Energy Research Faculty and Staff Publications

A better understanding of key fundamental properties of nitrosamines, including their solubility in aqueous amine solvents, is needed to understand and accurately model the vapor-phase emission levels from operating CO₂ capture systems. In this work, the first experimental Henry's volatility coefficient of a nitrosamine was obtained with a novel method using static headspace solid phase micro extraction (SPME) and gas chromatography mass spectrometry (GC/MS). The experimentally determined Henry's volatility coefficient of nitrosopyrrolidine (NPY) was found to be around 0.02 (dimensionless) at 25 °C, and falls in the range of a semi-volatile compound. A linear temperature dependency of the Henry's …

Solvent Degradation And Emissions From A 0.7mwe Pilot Co2 Capture System With Two-Stage Stripping, Jesse Thompson, Heather Nikolic, Megan Combs, Saloni Bhatnagar, Jonathan Pelgen, Keemia Abad, Kunlei Liu

Center for Applied Energy Research Faculty and Staff Publications

The UKy-CAER team successfully tested an advanced 0.7 MWe post-combustion CO₂ capture system on a coal-fired power plant using a heat integration process combined with two-stage stripping to enhance the CO₂ absorber performance. One of the unique feature of the UKy-CAER integrated process is a two-stage stripping unit for solvent regeneration. The secondary stripper is empowered by the heat rejection from a conventional steam-heated (primary) stripper. The secondary stripper outlet stream at the commercial scale can be used as boiler secondary combustion air, consequently enriching the flue gas with CO₂, resulting in less energy penalty required …

Mapping And Integrating Value Creation Factors With Life-Cycle Stages For Sustainable Manufacturing, P. Bilge, S. Emec, G. Seliger, Ibrahim S. Jawahir

Institute for Sustainable Manufacturing Faculty Publications

Instead of implementing each element individually, engineers must be aware of multiple interactions among all major value creation factors and their life-cycle stages. Interactions are analyzed by a set of factors and hierarchical levels within a production system based on empirical observations and described in analytical models. Such analyses and missing information about the current condition of the system and its parts remain limited to addressing specific aspects of interactions among factors and stages for multiple decision making. To build a case-based scope addressing the interactions among a set of factors and life-cycle stages, a comprehensive approach for mapping and …

An Experimental Investigation Of Wing-Tip Vortex Decay In Turbulence, Hai G. Ghimire, Sean C. C. Bailey

Mechanical Engineering Faculty Publications

Particle image velocimetry measurements were conducted for a wing-tip vortex decaying in free-stream turbulence. The vortex exhibited stochastic collapse with free-stream turbulence present, with the breakdown initiating earlier for higher levels of turbulence. An increased rate of decay of the vortex tangential velocity was also observed, increasing with increasing free-stream turbulence. The decay of the vortex tangential velocity without the free-stream turbulence was well represented by viscous diffusion, resulting in an increase in the core radius and decrease in the peak tangential velocity. With the addition of free-stream turbulence, the rate of decay of the peak tangential velocity of the …

Strategies For Value Creation Through Sustainable Manufacturing, Fazleena Badurdeen, Ibrahim S. Jawahir

Institute for Sustainable Manufacturing Faculty Publications

Making the business case and establishing strategic directions for sustainable manufacturing requires a collaborative effort. Strategic capabilities that can help create sustainable value for all stakeholders must be identified. Technologies and methodologies to provide these capabilities for implementation must then be developed, through public-private partnerships. This paper presents major business imperatives and strategic capabilities necessary to enable value creation through sustainable manufacturing identified based on extensive engagement with business leaders and industry professionals as well as academic experts and government agency representatives. The paper also presents a future vision for sustainable products, processes and systems that can be derived from …

Sustainable Manufacturing Performance Evaluation: Integrating Product And Process Metrics For Systems Level Assessment, Aihua Huang, Fazleena Badurdeen

Mechanical Engineering Faculty Publications

This paper builds on the previously developed product sustainability index (ProdSI) and process sustainability index (ProcSI), and presents a framework for sustainable manufacturing performance evaluation at the systems level. The framework is then used to propose a comprehensive set of metrics for the enterprise level following a five-stage metrics hierarchy (individual metrics, sub-clusters, clusters, sub-index and index). The 6R concept (reduce, reuse, recycle, recover, redesign and remanufacture), total life-cycle emphasis, and triple bottom line (TBL) are considered for selecting relevant metrics. Finally, the metrics are integrated to develop an index for enterprise level sustainability assessment and …

Intracellular Nanoparticle Dynamics Affected By Cytoskeletal Integrity, Martha E. Grady, Emmabeth Parrish, Matthew A. Caporizzo, Sarah C. Seeger, Russell J. Composto, David M. Eckmann

Mechanical Engineering Faculty Publications

The cell interior is a crowded chemical space, which limits the diffusion of molecules and organelles within the cytoplasm, affecting the rates of chemical reactions. We provide insight into the relationship between non-specific intracellular diffusion and cytoskeletal integrity. Quantum dots entered the cell through microinjection and their spatial coordinates were captured by tracking their fluorescence signature as they diffused within the cell cytoplasm. Particle tracking revealed significant enhancement in the mobility of biocompatible quantum dots within fibrosarcoma cells versus their healthy counterparts, fibroblasts, as well as in actin destabilized fibroblasts versus untreated fibroblasts. Analyzing the displacement distributions provided insight into …

Laser Shock Wave Assisted Patterning On Niti Shape Memory Alloy Surfaces, Dovletgeldi Seyitliyev, Peizhen Li, Khomidkhodza Kholikov, Byron Grant, Haluk E. Karaca, Ali O. Er

Mechanical Engineering Faculty Publications

An advanced direct imprinting method with low cost, quick, and less environmental impact to create thermally controllable surface pattern using the laser pulses is reported. Patterned micro indents were generated on Ni₅₀Ti₅₀ shape memory alloys (SMA) using an Nd:YAG laser operating at 1064 nm combined with suitable transparent overlay, a sacrificial layer of graphite, and copper grid. Laser pulses at different energy densities which generates pressure pulses up to 10 GPa on the surface was focused through the confinement medium, ablating the copper grid to create plasma and transferring the grid pattern onto the NiTi surface. Scanning …

Recoverable Stress Induced Two-Way Shape Memory Effect On Niti Surface Using Laser-Produced Shock Wave, Dovletgeldi Seyitliyev, Peizhen Li, Khomidkhodza Kholikov, Byron Grant, Zachary Thomas, Orhan Alal, Haluk E. Karaca, Ali O. Er

Mechanical Engineering Faculty Publications

The surfaces of Ni50Ti50 shape memory alloys (SMAs) were patterned by laser scribing. This method is more simplistic and efficient than traditional indentation techniques, and has also shown to be an effective method in patterning these materials. Different laser energy densities ranging from 5 mJ/pulse to 56 mJ/pulse were used to observe recovery on SMA surface. The temperature dependent heat profiles of the NiTi surfaces after laser scribing at 56 mJ/pulse show the partially-recovered indents, which indicate a "shape memory effect (SME)" Experimental data is in good agreement with theoretical simulation of laser induced shock wave propagation inside NiTi SMAs. …

Fourth-Generation Fan Assessment Numeration System (Fans) Design And Performance Specifications, Michael P. Sama, George B. Day, Laura M. Pepple, Richard S. Gates

Biosystems and Agricultural Engineering Faculty Publications

The Fan Assessment Numeration System (FANS) is a measurement device for generating ventilation fan performance curves. Three different-sized FANS currently exist for assessing ventilation fans commonly used in poultry and livestock housing systems. All FANS consist of an array of anemometers inside an aluminum shroud that traverse the inlet or outlet of a ventilation fan. The FANS design has been updated several times since its inception and is currently in its fourth-generation (G4). The current design iteration (FANS-G4) is reported in this article with an emphasis on the hardware and software control, data acquisition systems, and operational reliability. Six FANS-G4 …

Simulation Of Horse-Fence Contact And Interaction Affecting Rotational Falls In The Sport Of Eventing, Gregorio Robles Vega

Theses and Dissertations--Mechanical Engineering

Rotational falls, or somersault falls, have led to serious and fatal injuries during the cross-country phase of Eventing competitions. Research to improve the safety of the sport began in 2000 after five fatal injuries occurred in the 1999 Eventing season. These efforts led to safety devices such as air jackets, improved helmets, and frangible/deformable fences. The focus of this thesis is to develop a more complete understanding of the horse-fence interaction as the approach motion transitions to a rotational fall. To achieve this, a large distribution of inertial properties was compiled through the development of a cylinder-based inertia approximation and …

Investigation Of An Axial Flow Rotary Valve Seal, Joseph K. Stieha

Theses and Dissertations--Mechanical Engineering

This thesis investigates potential materials to be used in the rotary sealing industry that provide low power loss and minimize cost. The studied rotary valve utilizes slots that act as timing valves to allow for flow axially, through the seal face, at particular times within a heat pump cycle. This investigation examines various combinations of multiple PTFE materials, plastics, and soft metals that have been proven to provide low friction coefficients. Leakage and wear requirements are stated for the future use of the rotary valve and are used to determine the effectiveness of sealing the fluid while examining the power …

Investigation Of Polishing Methods And Surface Analysis After Machining Aisi 4140 Alloy Steel, Qiang Qi

Theses and Dissertations--Mechanical Engineering

AISI 4140 alloy steel has been a very common material to be investigated in automotive and aerospace industries for several decades. AISI 4140 alloy steel is chromium, molybdenum, and manganese containing low alloy steel. It has high fatigue strength, abrasion and impact resistance, toughness, and torsional strength. The functional performance is largely determined by the surface states after machining.

The aim of the present study is to explore the polishing methods and surface analysis after machining AISI 4140 alloy steel in different cutting speeds and cooling conditions. The surface analysis includes surface roughness, hardness and residual stresses. Compared to traditional …