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Full-Text Articles in Mechanical Engineering
The Influence Of 3d Porous Chitosan-Alginate Biomaterial Scaffold Properties On The Behavior Of Breast Cancer Cells, Minh-Chau N. Le
The Influence Of 3d Porous Chitosan-Alginate Biomaterial Scaffold Properties On The Behavior Of Breast Cancer Cells, Minh-Chau N. Le
Honors Undergraduate Theses
The tumor microenvironment plays an important role in regulating cancer cell behavior. The tumor microenvironment describes the cancer cells, and the surrounding endothelial cells, fibroblasts, and mesenchymal stem cells, along with the extracellular matrix (ECM). The tumor microenvironment stiffens as cancer undergoes malignant progression, providing biophysical cues that promote invasive, metastatic cellular behaviors. This project investigated the influence of three dimensional (3D) chitosan-alginate (CA) scaffold stiffness on the morphology, growth, and migration of green fluorescent protein (GFP) – transfected MDA-MB-231 (231-GFP) breast cancer (BCa) cells. The CA scaffolds were produced by the freeze casting method at three concentrations, 2 wt%, …
Computational Fluid Dynamics Investigation Of A Novel Hybrid Comprehensive Stage Ii Operation For Single Ventricle Palliation, Marwan Hameed
Computational Fluid Dynamics Investigation Of A Novel Hybrid Comprehensive Stage Ii Operation For Single Ventricle Palliation, Marwan Hameed
Electronic Theses and Dissertations
Hypoplastic left heart syndrome (HLHS) is a type of heart defect where the left ventricle is underdeveloped or not developed, resulting in only a single functioning right ventricle. Approximately 7.5% of patients with congenital heart disease are born with a single ventricle (SV) which is accompanied by a spectrum of other malformations such as atrophied ascending aorta, atrial septal defects, and ventricular septal defects (VSD). The existing three-hybrid staged surgical approach serving as a palliative treatment for this anomaly entails multiple complications and achieves a survival rate of only 50%. To reduce the trauma associated with the second stage of …
Probing The Influence Of Cx43 And Glucose On Endothelial Biomechanics, Md Mydul Islam
Probing The Influence Of Cx43 And Glucose On Endothelial Biomechanics, Md Mydul Islam
Electronic Theses and Dissertations
Endothelial cells (ECs) form the innermost layer of all vasculature and constantly receive both biochemical and biomechanical signals, yielding a plethora of biomechanical responses. In response to various biochemical or biomechanical cues, ECs have been documented to generate biomechanical responses such as tractions and intercellular stresses between the cell and substrate and between adjacent cells in a confluent monolayer, respectively. Thus far, the ability of endothelial tight junctions and adherens junctions to transmit intercellular stresses has been actively investigated, but the role of gap junctions is currently unknown. In addition, there is no report of the independent influence of hyperglycemia …