Mechanical Engineering Commons^™

Micro-Architectured Metamaterials: Design And Analysis, Li Ai

Mechanical Engineering Research Theses and Dissertations

Metamaterials are engineered materials with unusual properties deriving mainly from their micro-architectures rather than composition. They have attracted increasing attention owing to their tailorable multi-functional properties that cannot be exhibited by naturally-occurring or traditionally-manufactured materials. Materials with a negative Poisson’s ratio (PR) and materials with a non-positive coefficient of thermal expansion (CTE) are examples of mechanical metamaterials. In this dissertation, metamaterials with negative Poisson’s ratios and negative coefficients of thermal expansion are designed using both heuristic approaches and topology optimization methods.

Firstly, based on a star-shaped re-entrant structure, three two-dimensional (2-D) periodic cellular materials are developed, which can be tailored …

Multiple Consecutive Recapture Of Rigid Nanoparticles Using A Solid-State Nanopore Sensor, Jungsoo Lee

Mechanical Engineering Research Theses and Dissertations

Solid‐state nanopore sensors have been used to measure the size of a nanoparticle by applying a resistive pulse sensing technique. Previously, the size distribution of the population pool could be investigated utilizing data from a single translocation, however, the accuracy of the distribution is limited due to the lack of repeated data. In this study, we characterized polystyrene nanobeads utilizing single particle recapture techniques, which provide a better statistical estimate of the size distribution than that of single sampling techniques. The pulses and translocation times of two different sized nanobeads (80 nm and 125 nm in diameter) were acquired repeatedly …

Cancer Diagnosis By Bioimpedance Spectroscopy And Computer-Assisted Pattern Recognition, Shahriar Shams

Mechanical Engineering Research Theses and Dissertations

The field of cancer diagnostics has always been one of the most complex and challenging areas in biomedical research, and there has been an increasing demand for more advanced clinical diagnostic equipment over the past four decades. In this thesis, a custom-made coaxial bioimpedance sensor was used, in combination with computer-aided pattern recognition tools, to identify cancer in tissue samples obtained from the formalin-fixed kidney of a 60 year-old male patient. Impedance data was collected using the coaxial sensor at 401 logarithmically-spaced frequency points ranging from 10 kHz to 100 MHz. Principle Component Analysis and Naive Bayes Classification techniques were …