Mechanical Engineering Commons^™

Interactions Of Bacteria With Monolithic Lateral Silicon Nanospikes Inside A Microfluidic Channel, Lei Li, Feng Tian, Hao Chang, Jie Zhang, Cheng Wang, Wei Rao, Huan Hu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

This paper presents a new strategy of integrating lateral silicon nanospikes using metal-assisted chemical etching (MacEtch) on the sidewall of micropillars for on-chip bacterial study. Silicon nanospikes have been reported to be able to kill bacteria without using chemicals and offer a new route to kill bacteria and can prevent the overuse of antibiotics to reduce bacteria. We demonstrated a new methodology to fabricate a chip with integrated silicon nanospikes onto the sidewalls of micropillars inside the microfluidic channel and attested its interactions with the representative gram-negative bacteria Escherichia coli. The results of colony-forming unit (CFU) calculation showed that 80% …