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Full-Text Articles in Mechanical Engineering
Simulating The Growth Of Articular Cartilage Explants In A Permeation Bioreactor To Aid In Experimental Protocol Design, Timothy P. Ficklin, Andrew Davol, Stephen M. Klisch
Simulating The Growth Of Articular Cartilage Explants In A Permeation Bioreactor To Aid In Experimental Protocol Design, Timothy P. Ficklin, Andrew Davol, Stephen M. Klisch
Mechanical Engineering
Recently a cartilage growth finite element model (CGFEM) was developed to solve nonhomogeneous and time-dependent growth boundary-value problems (Davol et al., 2008, “A Nonlinear Finite Element Model of Cartilage Growth,” Biomech. Model. Mechanobiol., 7, pp. 295–307). The CGFEM allows distinct stress constitutive equations and growth laws for the major components of the solid matrix, collagens and proteoglycans. The objective of the current work was to simulate in vitro growth of articular cartilage explants in a steady-state permeation bioreactor in order to obtain results that aid experimental design. The steady-state permeation protocol induces different types of mechanical stimuli. When the specimen …
Articular Cartilage Mechanical And Biochemical Property Relations Before And After In Vitro Growth, Timothy Ficklin, Gregory Thomas, James C. Barthel, Anna Asanbaeva, Eugene J. Thonar, Koichi Masuda, Albert C. Chen, Robert L. Sah, Andrew Davol, Stephen M. Klisch
Articular Cartilage Mechanical And Biochemical Property Relations Before And After In Vitro Growth, Timothy Ficklin, Gregory Thomas, James C. Barthel, Anna Asanbaeva, Eugene J. Thonar, Koichi Masuda, Albert C. Chen, Robert L. Sah, Andrew Davol, Stephen M. Klisch
Mechanical Engineering
The aim of this study was to design in vitro growth protocols that can comprehensively quantify articular cartilage structure–function relations via measurement of mechanical and biochemical properties. Newborn bovine patellofemoral groove articular cartilage explants were tested sequentially in confined compression (CC), unconfined compression (UCC), and torsional shear before (D0, i.e. day zero) and after (D14, i.e. day 14) unstimulated in vitro growth. The contents of collagen (COL), collagen-specific pyridinoline (PYR) crosslinks, glycosaminoglycan, and DNA significantly decreased during in vitro growth; consequently, a wide range of biochemical properties existed for investigating structure–function relations when pooling the D0 and D14 groups. All …
Volumetric Growth Of Thermoelastic Materials And Mixtures, Stephen M. Klisch, Anne Hoger
Volumetric Growth Of Thermoelastic Materials And Mixtures, Stephen M. Klisch, Anne Hoger
Mechanical Engineering
The proteoglycan and collagen constituents of cartilage serve distinct mechanical roles. Changes to the mechanical loading conditions during cartilage growth lead to changes in the concentrations of these molecules and, consequently, the mechanical properties. The main aim of this paper is to present a theory that can describe the mechanical aspects of cartilage growth. The model for cartilage growth is based on a general thermomechanical theory for a mixture of an arbitrary number of growing elastic constituents and an inviscid fluid. Our development of a growth mixture theory is accomplished in two steps. First, the thermodynamics of growing elastic materials …
A Theory Of Volumetric Growth For Compressible Elastic Biological Materials, Stephen M. Klisch, Timothy J. Van Dyke, Anne Hoger
A Theory Of Volumetric Growth For Compressible Elastic Biological Materials, Stephen M. Klisch, Timothy J. Van Dyke, Anne Hoger
Mechanical Engineering
A general theory of volumetric growth for compressible elastic materials is presented. The authors derive a complete set of governing equations in the present configuration for an elastic material undergoing a continuous growth process. In particular, they obtain two constitutive restrictions from a work-energy principle. First, the authors show that a growing elastic material behaves as a Green-elastic material. Second, they obtain an expression that relates the stress power due to growth to the rate of energy change due to growth. Then, the governing equations for a small increment of growth are derived from the more general theory. The equations …