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Antioxidant; biomaterial; gallic acid; gelatin; pilocarpine; animal; chemistry; drug release; electroretinography
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Full-Text Articles in Mechanical Engineering
In Vivo Pharmacological Evaluations Of Pilocarpine-Loaded Antioxidant-Functionalized Biodegradable Thermogels In Glaucomatous Rabbits, Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
In Vivo Pharmacological Evaluations Of Pilocarpine-Loaded Antioxidant-Functionalized Biodegradable Thermogels In Glaucomatous Rabbits, Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
Mechanical Engineering Faculty Publications and Presentations
To alleviate oxidative stress-induced ocular hypertension, grafting of antioxidant molecules to drug carriers enables a dual-function mechanism to effectively treat glaucomatous intraocular pressure (IOP) dysregulation. Providing potential application for intracameral administration of antiglaucoma medications, this study, for the first time, aims to examine in vivo pharmacological efficacy of pilocarpine-loaded antioxidant-functionalized biodegradable thermogels in glaucomatous rabbits. A series of gallic acid (GA)-grafted gelatin-g-poly(N-isopropylacrylamide) (GN) polymers were synthesized via redox reactions at 20-50 °C. Our results showed that raising redox radical initiation reaction temperature maximizes GA grafting level, antioxidant activity, and water content at 40 °C. Meanwhile, increase in overall hydrophilicity of …