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Full-Text Articles in Mechanical Engineering
Peridynamic Modeling Of Dynamic Fracture In Bio-Inspired Structures For High Velocity Impacts, Sneha Akula
Peridynamic Modeling Of Dynamic Fracture In Bio-Inspired Structures For High Velocity Impacts, Sneha Akula
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Bio-inspired damage resistant models have distinct patterns like brick-mortar, Voronoi, helicoidal etc., which show exceptional damage mitigation against high-velocity impacts. These unique patterns increase damage resistance (in some cases up to 3000 times more than the constituent materials) by effectively dispersing the stress waves produced by the impact. Ability to mimic these structures on a larger scale can be ground-breaking and could be used in numerous applications. Advancements in 3D printing have now made possible fabrication of these patterns with ease and at a low cost. Research on dynamic fracture in bio-inspired structures is very limited but it is …
Surface Charge Switchable And Ph-Responsive Chitosan/Polymer Core-Shell Composite Nanoparticles For Drug Delivery Application, W. F. Huang, C. P. Tsui, M. Yang, Linxia Gu
Surface Charge Switchable And Ph-Responsive Chitosan/Polymer Core-Shell Composite Nanoparticles For Drug Delivery Application, W. F. Huang, C. P. Tsui, M. Yang, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
The mutually conflicting surface charge requirements for nanoparticles to have long circulation and good cell affinity have made the development of polymer nanoparticles for controlled drug delivery fall into a dilemma. In order to solve this problem, the first attempt has been made in this work to develop vancomycin loaded composite nanoparticles with a novel chitosan core and poly (lactide-co-glycolide) (PLGA) shell structure and with both pH-responsive and surface charge switchable properties. Spherical composite nanoparticles have been successfully fabricated through a modified emulsion-gelation method with a controllable size (316–573 nm), surface charge (–27.6–31.75 mV) and encapsulation efficiency up to 70.8%. …