Mechanical Engineering Commons^™

Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb

Theses and Dissertations

Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …

Pulse Modulation In Braided Pneumatic Actuators Mimics Contractile Behavior Of Biological Muscles, Mohamad Elzein

Student Research Symposium

Advancements in robotics and bioengineering aim to emulate biological muscle systems through robotic actuators, blending mechanical strength with biological adaptability. A lesser-explored aspect is mimicking the pulse-like control characteristic of biological muscles, which contract in response to action potentials from motoneurons, with muscle contractile force relying heavily on the timing between these potentials. This study explores the effect of pulse lengths and the gaps between pulses on braided pneumatic actuators (BPAs), which mimic the nonlinearity and dynamic response of biological muscles. It hypothesizes that artificial muscles utilizing pulse-based control will exhibit a similar force dependency on the intervals between pulses …

Model-Based Comparison Of Biological Organism And Electro-Mechanical System Resiliency Strategies, Nicholas Ratycz

Mechanical Engineering Undergraduate Honors Theses

Bio-inspired design has been used by many engineers to solve difficult problems or to make manufacturing processes more efficient. Biomimetics is the study of implementing the structure or function of biological substances, materials, mechanisms, and processes onto artificial ones that mimic the original. The goal of the BIASD tool is to provide bio-inspiration for engineers by studying the fault-adaptive strategies that biological systems use, rather than just their structure or function. In this thesis, the fault adaptive strategies of both a biological example and that of a real cubesat are compared using three types of model-based system diagrams to show …

Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of Gait, Timothy S. Jain

Master's Theses

Total ankle replacement (TAR) implants are an effective option to restore the range of motion of the ankle joint for arthritic patients. An effective tool for analyzing these implants’ mechanical performance and longevity in-silico is finite element analysis (FEA). ABAQUS FEA was used to statically analyze the von Mises stress and contact pressure on the articulating surface of the bearing component in two newly installed fixed-bearing total ankle replacement implants (the Wright Medical INBONE II and the Exactech Vantage). This bearing component rotates on the talar component to induce primary ankle joint motion of plantarflexion and dorsiflexion. The stress response …

A Novel Magnetorheological Pump Concept For Insulin Delivery, Mohammad Towhidul Islam Rimon

Electronic Theses and Dissertations

Over the past 25 years, awareness of type 1 diabetes has significantly increased, leading to a comprehensive understanding of various aspects, including its genetics, epidemiology, and disease burden. According to the Type 1 Diabetic Index, about 8.7 million people around the world live with this long-term autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. However, the increased availability and utilization of artificial pancreas systems could potentially save 673,000 lives by 2040. Although, the advancement of diabetes technology offers Type 1 diabetic patients more tools to enhance glycemic management and achieve effective outcomes, many patients are still hesitant to adopt …

Simultaneous Evaluation Of Tibiofemoral And Patellofemoral Mechanics In Total Knee Arthroplasty: A Combined Experimental And Computational Approach, Yashar A. Behnam, Ahilan Anantha Krishnan, Hayden Wilson, Chadd W. Clary

Center for Orthopaedic Biomechanics: Faculty Scholarship

Contemporary total knee arthroplasty (TKA) has not fully restored natural patellofemoral (P-F) mechanics across the patient population. Previous experimental simulations have been limited in their ability to create dynamic, unconstrained, muscle-driven P-F articulation while simultaneously controlling tibiofemoral (T-F) contact mechanics. The purpose of this study was to develop a novel experimental simulation and validate a corresponding finite element model to evaluate T-F and P-F mechanics. A commercially available wear simulator was retrofitted with custom fixturing to evaluate whole-knee TKA mechanics with varying patella heights during a simulated deep knee bend. A corresponding dynamic finite element model was developed to validate …

Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail

Theses and Dissertations

Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …

Numerical Investigation Of Subglottal Stenosis Effects On Human Voice Production, Dariush Bodaghi

Electronic Theses and Dissertations

This dissertation aimed to advance knowledge of how subglottal stenosis impacts voice production physiology. An in-house fluid-structure-acoustic interaction approach based on the hydrodynamic/acoustic splitting technique was employed. This technique was rigorously verified for simulating phonation by matching the acoustic behavior to a compressible flow solver for phonation-relevant geometries. Simulations of an idealized 2D vocal tract model demonstrated the effects of supraglottal acoustic resonance on vocal fold kinematics and glottal flow waveform. Results showed that the acoustic coupling between higher harmonics and formats generated pressure oscillations, modifying vocal fold dynamics and glottal flow rate.

A major novelty was the incorporation and …

Characterizing Tkr Biomechanics Using A Novel Muscle-Driven Joint Motion Simulator, Alexandre Galley

Electronic Thesis and Dissertation Repository

Total knee replacement (TKR) is the end-stage treatment for severe cases of knee osteoarthritis (OA). Despite its success in alleviating pain and restoring mobility to the knee, patient satisfaction rates post-TKR are still lower than other common joint replacement surgeries. Knee kinematics and stability, key determinants of successful TKR, are assessed intraoperatively and tracked post-operatively in in vivo clinical studies. However, the persistently low satisfaction rates suggest that more sophisticated pre-clinical testing methods are needed to better understand the biomechanics of these implants early in their development. During pre-clinical testing of TKR implants, different joint motion simulators are used for …

Understanding Real-World And Laboratory Traumatic Brain Injury (Tbi) Using The Computational Model With Brain Functional Regions, Kewei Bian

Electronic Thesis and Dissertation Repository

Traumatic brain injury (TBI), including mild traumatic brain injury (mTBI) or concussion, is a severe health concern. Many symptoms, such as headache, dizziness, and working memory deficits, are reported to be related to the dysfunction of brain functional regions, but the underlying mechanism remains unknown. Hence, further developing tools and analyses to understand brain dysfunction for better TBI prevention are important. Additionally, such analyses should be conducted for both real-world TBI cases and laboratory studies, as TBI data can only be collected from the real world, and prevention measures, such as helmets, are developed and evaluated in the lab. Accordingly, …

Development And Biomechanical Analysis Toward A Mechanically Passive Wearable Shoulder Exoskeleton, Seyyed Morteza Asgari

Doctoral Dissertations

Shoulder disability is a prevalent health issue associated with various orthopedic and neurological conditions, like rotator cuff tear and peripheral nerve injury. Many individuals with shoulder disability experience mild to moderate impairment and struggle with elevating the shoulder or holding the arm against gravity. To address this clinical need, I have focused my research on developing wearable passive exoskeletons that provide continuous at-home movement assistance. Through a combination of experiments and computational tools, I aim to optimize the design of these exoskeletons.

In pursuit of this goal, I have designed, fabricated, and preliminarily evaluated a wearable, passive, cam-driven shoulder exoskeleton …

Computational Modeling Using A Novel Continuum Approach Coupled With Pathway-Informed Neural Networks To Optimize Dynein-Mediated Centrosome Positioning In Polarized Cells, Arkaprovo Ghosal, Padmanabhan Seshaiyar Dr., Adriana Dawes Dr., General Genomics Inc.

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Kinematic Analysis Of Gait And Deep Knee Flexion For Pre- And Post-Operative Total Knee Arthroplasty, Samantha Collins

Electronic Theses and Dissertations

Osteoarthritis (OA) is a form of arthritis that develops in the joint due to overuse and aging causing pain, discomfort, and disability. Total Knee Arthroplasty (TKA) is a surgical procedure performed when OA symptoms are severe with an estimated 600,000 patients in the United States currently receiving TKA. Studies have reported dissatisfaction of the knee for 14-39% of patients. This study collected knee kinematics before and after surgery using stereo radiography for precise measurement of gait and deep knee flexion activities. Results showed healthy knee kinematics were not restored and no significant changes could be seen from OA kinematics in …

Exploration Of Motion Capture System To Investigate Human Shoulder Kinematics, Ola Alsaadi

Electronic Theses and Dissertations

The glenohumeral joint (GH) is commonly conceptualized as a ball-and-socket joint [1], and its center of rotation (COR) is presumed to coincide with the geometric center of the medial-superior region of the humeral head [2]. Recent research has endorsed improvements in COR estimation through invasive and noninvasive techniques, including cadaver studies, stereophotogrammetry, and motion capture (MOCAP) systems. Despite increased interest in wearable technology within human movement analysis, the problem of COR estimation employing MOCAP systems and its validation against bi-planar fluoroscopy remains relatively unexplored.

This study employed a marker-based MOCAP system to compare the accuracy, error, and precision of three …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Changes In Balance With Brain Inflammation: Sensitivity In Dual Motor Mechanisms, Hannah Mcdade

Electronic Theses and Dissertations

Concussion assessment in athletes has gained prominence due to potential long-term consequences of traumatic brain injuries. Evaluating balance alterations is crucial for understanding post-injury motor control strategies. This study introduces a novel approach to understanding center of pressure (COP) dynamics during quiet stance tasks for assessing balance impairments in athletes recovering from concussion. Concussed athletes often experience impaired motor function and cognitive deficits, increasing the risk of orthopedic injury. Traditional balance assessments focus on total COP (COPt), overlooking nuanced hip and ankle mechanisms. This research investigates COP variations between constant loading (COPc) and variable loading (COPv) signals in concussed athletes …

Computational Methodology For Generating Patient-Specific Soft Tissue Representations, Ahilan Anantha Krishnan

Electronic Theses and Dissertations

This dissertation focused on modeling specimen-specific soft tissue structures in the context of joint replacement surgery. The research addressed four key aspects. The first study involved developing a workflow for creating finite element models of the hip capsule to replicate its torque-rotational response. Experimental data from ten cadaveric hips were used to calibrate the models, resulting in improved accuracy and relevance for surgical planning and implant design. The second study tackled the challenge of expediting the calibration of mechanical properties of the hip capsule to match patient-specific laxities. A statistical shape function model was proposed to generate patient-specific finite element …

Exoskeletons - Designing For Social Justice, Grace Cd Murphy

College of Engineering Summer Undergraduate Research Program

Many engineering professionals believe that discussions surrounding diversity, equity, and inclusion (DEI), and social justice do not belong in engineering because engineering is supposed to be a neutral or objective field. Through an extensive review of the literature and a survey sent out to potential users, the need for DEI in engineering was examined. Many current engineering projects do not take into consideration social justice principles which leaves certain groups further marginalized and disempowered while empowering a select few. Engineering has the opportunity to be a field of service, but first risks and benefits must be weighed and the outcome …

Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland

Mechanical & Aerospace Engineering Theses & Dissertations

Inactive adults often have decreased musculoskeletal health and increased risk factors for chronic diseases. However, there is limited data linking biomechanical measurements of generally healthy young adults to their physical activity levels assessed through questionnaires. Commonly used data collection methods in biomechanics for assessing musculoskeletal health include but are not limited to muscle quality (measured as echo intensity when using ultrasound), isokinetic (i.e., dynamic) muscle strength, muscle activations, and functional movement assessments using motion capture systems. These assessments can be time consuming for both data collection and processing. Therefore, understanding if all biomechanical assessments are necessary to classify the activity …

Analysis Of Gait Parameters And Knee Angles In Ultimate Frisbee Players: Implications For Balance And Injury, Ethan Nikcevich

Master's Theses

Biomechanics research investigating gait and balance of ultimate frisbee players is an unexplored topic. Ultimate requires a wide range of motions that could improve balance and is also a sport prone to frequent injury. This study explores the impact of playing ultimate on gait parameters associated with balance and knee angles associated with joint injury. Gait trials were conducted on 8 ultimate players and 8 control participants between the ages of 18 and 23 to obtain total double support time, stance phase time, single support time, load response time, abduction-adduction (AA) angles, internal-external (IE) rotation angles, and flexion angles of …

Modeling The Moisture Content And Drying Rate Of Zucchini (Cucurbita Pepo L.) In A Solar Hybrid Dryer Using Ann And Anfis Methods, Halil Nusret Bulus, Aytac Moralar, Soner Celen

The Philippine Agricultural Scientist

Estimating product drying kinetics is critical to obtain the best drying process without compromising product quality and necessitates the development of numerical drying models. This research aims to compare the prediction models developed using artificial neural network (ANN) and adaptive network-based fuzzy inference system (ANFIS), two popular machine learning approaches in the recent years. Zucchini slices were chosen as samples and dried in a solar-assisted microwave belt dryer at 0.245 m/min belt speed and microwave powers of 0.7, 1, and 1.4 kW. On the data set obtained by computing the moisture content and drying rate values, prediction models were developed …

Quantifying Balance: Computational And Learning Frameworks For The Characterization Of Balance In Bipedal Systems, Kubra Akbas

Dissertations

In clinical practice and general healthcare settings, the lack of reliable and objective balance and stability assessment metrics hinders the tracking of patient performance progression during rehabilitation; the assessment of bipedal balance plays a crucial role in understanding stability and falls in humans and other bipeds, while providing clinicians important information regarding rehabilitation outcomes. Bipedal balance has often been examined through kinematic or kinetic quantities, such as the Zero Moment Point and Center of Pressure; however, analyzing balance specifically through the body's Center of Mass (COM) state offers a holistic and easily comprehensible view of balance and stability.

Building upon …

Improving Irrigant Flow Characteristics For Enhanced Root Canal Therapy: A Numerical Study, Bibek Banjaday

Masters Theses

This numerical study investigates the flow characteristics within a root canal during a manual endodontic treatment. To underscore the difference in root canal geometry, a simplified root canal (frustum of a cone) and a more complex (realistic) root canal geometry were considered. The needle utilized in all simulations is a side-vented 30G KerrHaweIrrigation Probe, KerrHawe SA, Bioggio, Switzerland. For both root canal geometries, the effect of variation of fluid inlet velocity, needle insertion depth, and needle tilt angle on flow characteristics was examined via velocity contours, turbulent intensity, wall shear stress, and streamline and vector plots. The fluid was Sodium …

Enhancing Human Key Point Identification: A Comparative Study Of High-Resolution Vicon Dataset And Coco Dataset Using Bpnet, Bibash Lama

Masters Theses

Accurately identifying human key points is crucial for various applications, including activity recognition, pose estimation, and gait analysis. This study presents a high-resolution dataset created using the VICON motion capture system and three differently oriented 2D cameras, that can be used to train different neural networks for estimating the 2D key joint positions of the person from the 2D images or videos. The participants in the study included 25 healthy adults (17 males and 8 females) performing normal gait movements for about 2 to 3 seconds. The VICON system captured 3D ground truth data, while the three 2D cameras collected …

Hierarchical Based Classifcation Method Based On Fusion Ofgaussian Map Descriptors Foralzheimer Diagnosis Using T1‑Weighted Magnetic Resonance Imaging, Nourhan Zayed, Shereen E. Morsy, Inas A. Yassine

Mechanical Engineering

Alzheimer’s disease (AD) is considered one of the most spouting elderly diseases. In 2015, AD is reported the US’s sixth cause of death. Substantially, non-invasive imaging is widely employed to provide biomarkers supporting AD screening, diagnosis, and progression. In this study, Gaussian descriptors-based features are proposed to be efcient new biomarkers using Magnetic Resonance Imaging (MRI) T1-weighted images to diferentiate between Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), and Normal controls (NC). Several Gaussian map-based features are extracted such as Gaussian shape operator, Gaussian curvature, and mean curvature. The aforementioned features are then introduced to the Support Vector Machine (SVM). …

Hemodynamic Assessment Of Y-Incision Aortic Root Enlargement Using Computational Simulations, Astitwa Ghimire

Electronic Theses and Dissertations

The Yang procedure is a new aortic root enlargement technique used to enlarge the aortic annulus by multiple valve sizes. The procedure prevents patient prosthesis mismatch and establishes a viable platform for future valve-in-valve implantation. This study used the Yang procedure to investigate the hemodynamics in the aortic root and bioprosthetic valve regions after aortic root enlargement. Results indicate the velocity magnitude at the sinus regions of a patient who underwent the Yang procedure was slower, indicating risks of flow stasis and thrombosis. Simulation results denote computational models can be created for optimization of surgical procedures.

A Virtual Method For Establishing Femoral Stem Position In Total Hip Arthroplasty, Samuel Mattei

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most successful orthopedic surgeries performed, in which the hip joint is reconstructed to improve functionality and decrease pain in the joint. Despite the success of these procedures, femoral stem misalignment remains an area that influences THA success. The relationship between the femoral stem geometry and implanted femoral stem size and orientation is underreported due to limitations in the collection of radiographic data used for clinical pre-operative templating. Furthermore, the influence of anatomic measurements on the direction and size of the femoral stem are not considered due to imaging technique and difficulties associated …

Finite Element Modeling Of Patient-Specific Total Shoulder Arthroplasty, Ignacio Rivero Crespo

Electronic Theses and Dissertations

Total Shoulder Arthroplasty (TSA) is a surgical procedure designed to improve joint functionality by replacing the articulation between the humeral head and the glenoid fossa. Anatomic Total Shoulder Arthroplasty (aTSA) and Reverse Total Shoulder Arthroplasty (rTSA) are two types of replacement surgery to relieve pain and restore function of the shoulder. The overall goal of this study was to evaluate the effects of variation of certain patient and implant alignment parameters that may influence long-term outcomes of these surgical procedures, including kinematics, joint loads and contact mechanics. Computational models of six TSA subjects, three aTSA and three rTSA, were created …

Development Of A Soft Robotic Approach For An Intra-Abdominal Wireless Laparoscopic Camera, Hui Liu

Doctoral Dissertations

In Single-Incision Laparoscopic Surgery (SILS), the Magnetic Anchoring and Guidance System (MAGS) arises as a promising technique to provide larger workspaces and field of vision for the laparoscopes, relief space for other instruments, and require fewer incisions. Inspired by MAGS, many concept designs related to fully insertable magnetically driven laparoscopes are developed and tested on the transabdominal operation. However, ignoring the tissue interaction and insertion procedure, most of the designs adopt rigid structures, which not only damage the patients' tissue with excess stress concentration and sliding motion but also require complicated operation for the insertion. Meanwhile, lacking state tracking of …

Mechanical Response Of The Craniofacial Skeleton To Subfracture Impacts In The Time And Frequency Domains, Paige Merko

Electronic Thesis and Dissertation Repository

Resonant frequencies have been suggested as a mechanism of brain injury since these vibrations can transfer energy into the brain. Study of the vibrational response of the craniofacial skeleton to impact is limited in literature. In this research, four cadaver specimens were impacted at five locations on the craniofacial skeleton. The mechanical response to each impact was compared in the time and frequency domains. Impacts to the maxilla and its associated soft tissues tended to be attenuated, while impacts to the cranial vault, specifically to the occipital, produced the most severe response. Results suggest that the facial skeleton and its …